COL4A5 Polyklonaler Antikörper

COL4A5 Polyklonal Antikörper für ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human und mehr (2)

Anwendung

WB, IHC, IF, ELISA

Konjugation

Unkonjugiert

Publikationen(17)

Kat-Nr. : 19797-1-AP

Synonyme

Collagen alpha 5(IV) chain, Collagen alpha-5(IV) chain

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Geprüfte Anwendungen

Veröffentlichte Anwendungen

• WB: See 13 publications below
• IHC: See 2 publications below
• IF: See 4 publications below

Produktinformation

19797-1-AP bindet in WB, IHC, IF, ELISA COL4A5 und zeigt Reaktivität mit human

• Getestete Reaktivität: human
• In Publikationen genannte Reaktivität: human, Maus, Ratte
• Wirt / Isotyp: Kaninchen / IgG
• Klonalität: Polyklonal
• Typ: Antikörper
• Immunogen: Peptid
• Vollständiger Name: collagen, type IV, alpha 5
• Berechnetes Molekulargewicht: 161 kDa
• GenBank-Zugangsnummer: NM_000495
• Gene symbol: COL4A5
• Gene ID (NCBI): 1287
• Konjugation: Unkonjugiert
• Form: Liquid
• Reinigungsmethode: Antigen-Affinitätsreinigung
• Lagerungspuffer: PBS with 0.02% sodium azide and 50% glycerol
• Lagerungsbedingungen: Bei -20°C lagern. Nach dem Versand ein Jahr lang stabil Aliquotieren ist bei -20^oC Lagerung nicht notwendig. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

COL4A5 belongs to the type IV collagen family. Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen. Defects in COL4A5 are the cause of Alport syndrome X-linked (APSX). Deletions covering the N-terminal regions of COL4A5 and COL4A6, which are localized in a head-to-head manner, are the cause of diffuse leiomyomatosis with Alport syndrome (DL-ATS)which also known as esophageal and vulval leiomyomatosis with nephropathy or Alport syndrome and diffuse leiomyomatosis (ATS-DL).

Publikationen

Species	Application	Title
mouse	IF	Biomaterials; A novel bioscaffold with naturally-occurring extracellular matrix promotes hepatocyte survival and vessel patency in mouse models of heterologous transplantation.; Authors - Wei Yang
mouse	WB	PLoS Genet; Minor Type IV Collagen α5 Chain Promotes Cancer Progression through Discoidin Domain Receptor-1.; Authors - Qian Xiao
human	WB	FASEB J; Drastic induction of MMP-7 by cortisol in the human amnion: implications for membrane rupture at parturition.; Authors - Lu-Yao Wang
mouse	WB	Bioorg Chem; AT1, a small molecular degrader of BRD4 based on proteolysis targeting chimera technology alleviates renal fibrosis and inflammation in diabetic nephropathy; Authors - Meng Yang
mouse	IF	Sci Rep; Methanol fixed fibroblasts serve as feeder cells to maintain stem cells in the pluripotent state in vitro.; Authors - Yahui Ren
mouse	WB	Front Pharmacol; Sappanone a prevents diabetic kidney disease by inhibiting kidney inflammation and fibrosis via the NF-κB signaling pathway; Authors - Zhe Wang