COMMD5 Monoklonaler Antikörper
COMMD5 Monoklonal Antikörper für WB, Indirect ELISA
Wirt / Isotyp
Maus / IgG2a
Getestete Reaktivität
human, Ratte
Anwendung
WB, Indirect ELISA
Konjugation
Unkonjugiert
CloneNo.
1E10G6
Kat-Nr. : 67043-1-PBS
Synonyme
Geprüfte Anwendungen
Produktinformation
67043-1-PBS bindet in WB, Indirect ELISA COMMD5 und zeigt Reaktivität mit human, Ratten
Getestete Reaktivität | human, Ratte |
Wirt / Isotyp | Maus / IgG2a |
Klonalität | Monoklonal |
Typ | Antikörper |
Immunogen | COMMD5 fusion protein Ag18464 |
Vollständiger Name | COMM domain containing 5 |
Berechnetes Molekulargewicht | 25 kDa |
Beobachtetes Molekulargewicht | 15 kDa |
GenBank-Zugangsnummer | BC003055 |
Gene symbol | COMMD5 |
Gene ID (NCBI) | 28991 |
Konjugation | Unkonjugiert |
Form | Liquid |
Reinigungsmethode | Protein-A-Reinigung |
Lagerungspuffer | PBS only |
Lagerungsbedingungen | Store at -80°C. 20ul Größen enthalten 0,1% BSA. |
Hintergrundinformationen
COMM domain containing 5 (COMMD5, synonyms: HCARG, HT002) is a hypertension-related calcium-regulated gene. COMMD5 is negatively regulated by extracellular calcium concentration, and its basal mRNA levels were higher in hypertensive animals. Tissue distribution of COMMD5 shows a preponderance in the heart, stomach, jejunum, kidney (tubular fraction), liver, and adrenal gland (mainly in the medulla). COMMD5 mRNA is significantly more expressed in adult than in fetal organs, and its levels are decreased in tumors and cancerous cell lines. COMMD5 protein has no transmembrane domain, but contains 67% -helix content, a calcium-binding site, four putative "leucine zipper" motifs, and a nuclear receptor-binding domain. At the subcellular level, COMMD5 shows a nuclear localization.