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CREB3 Polyklonaler Antikörper

CREB3 Polyklonal Antikörper für WB, IF/ICC, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

WB, IF/ICC, Indirect ELISA

Konjugation

Unkonjugiert

Kat-Nr. : 11275-1-PBS

Synonyme

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  • Western Blot (WB) analysis of Jurkat cells using CREB3 Polyclonal antibody (11275-1-AP)

    WB analysis of Jurkat using 11275-1-AP (same clone as 11275-1-PBS)

    Jurkat cells were subjected to SDS PAGE followed by western blot with 11275-1-AP (CREB3 antibody) at dilution of 1:600 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 11275-1-PBS in a different storage buffer formulation.

  • Western Blot (WB) analysis of HeLa cells using CREB3 Polyclonal antibody (11275-1-AP)

    WB analysis of HeLa using 11275-1-AP (same clone as 11275-1-PBS)

    WB result of CREB3 antibody (11275-1-AP; 1:600; incubated at room temperature for 1.5 hours) with sh-Control and sh-CREB3 transfected HeLa cells. This data was developed using the same antibody clone with 11275-1-PBS in a different storage buffer formulation.

  • Immunohistochemistry (IHC) staining of human prostate cancer tissue using CREB3 Polyclonal antibody (11275-1-AP)

    IHC staining of human prostate cancer using 11275-1-AP (same clone as 11275-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human prostate cancer using 11275-1-AP (CREB3 antibody) at dilution of 1:50 (under 25x lens). This data was developed using the same antibody clone with 11275-1-PBS in a different storage buffer formulation.

  • Immunofluorescence (IF) / fluorescent staining of U2OS cells using CREB3 Polyclonal antibody (11275-1-AP)

    IF Staining of U2OS using 11275-1-AP (same clone as 11275-1-PBS)

    Immunofluorescent analysis of (4% PFA) fixed U2OS cells using CREB3 antibody (11275-1-AP) at dilution of 1:400 and CoraLite®488-Conjugated AffiniPure Goat Anti-Rabbit IgG(H+L). This data was developed using the same antibody clone with 11275-1-PBS in a different storage buffer formulation.

Geprüfte Anwendungen

Produktinformation

11275-1-PBS bindet in WB, IF/ICC, Indirect ELISA CREB3 und zeigt Reaktivität mit human

Getestete Reaktivität human
Wirt / Isotyp Kaninchen / IgG
Klonalität Polyklonal
Typ Antikörper
Immunogen CREB3 fusion protein Ag1823
Vollständiger Name cAMP responsive element binding protein 3
Berechnetes Molekulargewicht 44 kDa
Beobachtetes Molekulargewicht 40-64 kDa
GenBank-ZugangsnummerBC009402
Gene symbol CREB3
Gene ID (NCBI) 10488
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Antigen-Affinitätsreinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

CREB3, also named as LZIP and Luman, belongs to the bZIP family and ATF subfamily. It is a transcription factors activated upon intramembrane proteolysis (RIP), binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AG][AG]-3'), a sequence present in many viral and cellular promoters. CREB3 binds to and requires HCFC1 as a coactivator. The activity and expression are suppressed when the HCFC1-CREB3 complex binds with CREBZF. Participates in LKN-1/CCL15-induced chemotaxis signaling. CREB3 is N-glycosylated and released by proteolysis. So the MW of CREB3 emirate 40kd to 64kd (PMID: 12138176).