CREB5 Polyklonaler Antikörper

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CREB5 Polyklonal Antikörper für WB, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

WB, Indirect ELISA

Konjugation

Unkonjugiert

Kat-Nr. : 14196-1-PBS

Synonyme

CRE-BPa, CREBPA, CREB-5, CREB 5, cAMP-responsive element-binding protein 5

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  WB analysis of HepG2 using 14196-1-AP (same clone as 14196-1-PBS)

  HepG2 cells were subjected to SDS PAGE followed by western blot with 14196-1-AP (CREB5 antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 14196-1-PBS in a different storage buffer formulation.

• 

  WB analysis of HeLa using 14196-1-AP (same clone as 14196-1-PBS)

  HeLa cells were subjected to SDS PAGE followed by western blot with 14196-1-AP (CREB5 antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 14196-1-PBS in a different storage buffer formulation.

• 

  WB analysis of MCF-7 using 14196-1-AP (same clone as 14196-1-PBS)

  MCF7 cells were subjected to SDS PAGE followed by western blot with 14196-1-AP (CREB5 antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 14196-1-PBS in a different storage buffer formulation.

• 

  WB analysis of human brain using 14196-1-AP (same clone as 14196-1-PBS)

  human brain tissue were subjected to SDS PAGE followed by western blot with 14196-1-AP (CREB5 antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 14196-1-PBS in a different storage buffer formulation.

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Geprüfte Anwendungen

Produktinformation

14196-1-PBS bindet in WB, Indirect ELISA CREB5 und zeigt Reaktivität mit human

• Getestete Reaktivität: human
• Wirt / Isotyp: Kaninchen / IgG
• Klonalität: Polyklonal
• Typ: Antikörper
• Immunogen: CREB5 fusion protein Ag5399
• Vollständiger Name: cAMP responsive element binding protein 5
• Berechnetes Molekulargewicht: 57 kDa
• Beobachtetes Molekulargewicht: 57 kDa
• GenBank-Zugangsnummer: BC059400
• Gene symbol: CREB5
• Gene ID (NCBI): 9586
• Konjugation: Unkonjugiert
• Form: Liquid
• Reinigungsmethode: Antigen-Affinitätsreinigung
• Lagerungspuffer: PBS only
• Lagerungsbedingungen: Store at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

cyclic AMP responsive element binding protein 5 (CREB5), also known as CRE-BPA, a member of the cAMP response element binding protein family, is a transcription factor specifically expressed in superficial zone articular chondrocytes and is required for TGF-β and EGFR signaling. Knockdown of CREB5 decreased the c-jun and c-fos expression levels in HC-a cells (PMID: 38549717). Increased CREB5 expression is positively correlated with tumor cell invasion and a poor prognosis for cancer patients with epithelial ovarian cancer and hepatocellular carcinoma (PMID: 38418476).This protein specifically binds to CRE as a homodimer or a heterodimer with c-Jun or CRE-BP1, and functions as a CRE-dependent trans-activator. Alternatively spliced transcript variants encoding different isoforms have been identified (PMID: 33712729).