CSF1R/CD115 Rekombinanter Antikörper

CSF1R/CD115 Rekombinant Antikörper für FC

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

FC

Konjugation

Unkonjugiert

CloneNo.

250001D7

Kat-Nr. : 98379-3-PBS

Synonyme

CSF1R, C FMS, CD115, CSF 1 R, CSF-1 receptor

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  FC experiment of human PBMCs using 98379-3-RR (same clone as 98379-3-PBS)

  1x10^6 human PBMCs were surface stained with 0.25 ug Anti-Human CSF1R/CD115 Rabbit RecAb (98379-3-RR, Clone:250001D7) or Rabbit IgG Isotype Control RecAb (98136-1-RR, Clone: 240953C9), and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were incubated with FC Receptor Block prior to staining. Cells were not fixed. This data was developed using the same antibody clone with 98379-3-PBS in a different storage buffer formulation.

• 

  FC experiment of human PBMCs using 98379-3-RR (same clone as 98379-3-PBS)

  1x10^6 human PBMCs were surface stained with 0.25 ug Anti-Human CSF1R/CD115 Rabbit RecAb (98379-3-RR, Clone: 250001D7) (red) or Rabbit IgG Isotype Control RecAb (98136-1-RR, Clone: 240953C9) (blue), and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were incubated with FC Receptor Block prior to staining. Cells were not fixed. This data was developed using the same antibody clone with 98379-3-PBS in a different storage buffer formulation.

• 

  Affinity and Kinetic Characterization of 98379-3-RR

  Biolayer interferometry (BLl) kinetic assays of 98379-3-RR against Human CSF1R/CD115 were performed. The affinity constant is 1.62 nM.

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Geprüfte Anwendungen

Produktinformation

98379-3-PBS bindet in FC CSF1R/CD115 und zeigt Reaktivität mit human

• Getestete Reaktivität: human
• Wirt / Isotyp: Kaninchen / IgG
• Klonalität: Rekombinant
• Typ: Antikörper
• Immunogen: Rekombinantes Protein
• Vollständiger Name: colony stimulating factor 1 receptor
• Berechnetes Molekulargewicht: 972 aa, 108 kDa
• GenBank-Zugangsnummer: BC047521
• Gene symbol: CSF1R/CD115
• Gene ID (NCBI): 1436
• Konjugation: Unkonjugiert
• Form: Liquid
• Reinigungsmethode: Protein-A-Reinigung
• Lagerungspuffer: PBS only
• Lagerungsbedingungen: Store at -80°C.

Hintergrundinformationen

The CSF-1 receptor (CSF1R), also called CD115, is activated by the homodimeric growth factors colony-stimulating factor-1 (CSF-1) and interleukin-34 (IL-34). It plays important roles in development and in innate immunity by regulating the development of most tissue macrophages and osteoclasts, of Langerhans cells of the skin, of Paneth cells of the small intestine, and of brain microglia. It also regulates the differentiation of neural progenitor cells and controls functions of oocytes and trophoblastic cells in the female reproductive tract. Owing to this broad tissue expression pattern, it plays a central role in neoplastic, inflammatory, and neurological diseases.