CTDSP1 Polyklonaler Antikörper

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• KD/KO Validated

CTDSP1 Polyklonal Antikörper für WB, ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human, Maus, Ratte

Anwendung

WB, ELISA

Konjugation

Unkonjugiert

Publikationen

4

Kat-Nr. : 10952-1-AP

Synonyme

CTDSP1, NIF3, NLI IF, NLI interacting factor 3, NLIIF, SCP1, Small CTD phosphatase 1

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Galerie der Validierungsdaten

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  WB analysis of mouse liver using 10952-1-AP

  mouse liver tissue were subjected to SDS PAGE followed by western blot with 10952-1-AP (CTDSP1 Antibody) at dilution of 1:300 incubated at room temperature for 1.5 hours.

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  WB analysis of mouse heart using 10952-1-AP

  mouse heart tissue were subjected to SDS PAGE followed by western blot with 10952-1-AP (CTDSP1 Antibody) at dilution of 1:300 incubated at room temperature for 1.5 hours.

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Geprüfte Anwendungen

• Erfolgreiche Detektion in WB: Mauslebergewebe, Mausherzgewebe

Empfohlene Verdünnung

• Western Blot (WB): WB : 1:200-1:1000

It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Sample-dependent, check data in validation data gallery

Veröffentlichte Anwendungen

• KD/KO: See 1 publications below
• WB: See 4 publications below

Produktinformation

10952-1-AP bindet in WB, ELISA CTDSP1 und zeigt Reaktivität mit human, Maus, Ratten

• Getestete Reaktivität: human, Maus, Ratte
• In Publikationen genannte Reaktivität: human, Maus
• Wirt / Isotyp: Kaninchen / IgG
• Klonalität: Polyklonal
• Typ: Antikörper
• Immunogen: CTDSP1 fusion protein Ag1410
• Vollständiger Name: CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1
• Berechnetes Molekulargewicht: 29 kDa
• Beobachtetes Molekulargewicht: 29-33 kDa
• GenBank-Zugangsnummer: BC012977
• Gene symbol: CTDSP1
• Gene ID (NCBI): 58190
• Konjugation: Unkonjugiert
• Form: Liquid
• Reinigungsmethode: Antigen-Affinitätsreinigung
• Lagerungspuffer: PBS mit 0.02% Natriumazid und 50% Glycerin pH 7.3.
• Lagerungsbedingungen: Bei -20°C lagern. Nach dem Versand ein Jahr lang stabil Aliquotieren ist bei -20^oC Lagerung nicht notwendig. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

CTDSP1 also named as NIF3, NLIIF, or SCP1, is a 261 amino acid protein, which contains one FCP1 homology domain. CTDSP1 localizes in the nucleus and colocalizes with RNA polymerase II. CTDSP1 is expressed in non-neuronal tissues. It is highly expressed in skeletal muscle, spleen, lung and placenta. CTDSP1 preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residues repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2.

Publikationen

Species	Application	Title
human	WB	J Biol Chem; Phosphatase activity of Small C-terminal domain phosphatase 1 (SCP1) controls the stability of the key neuronal regulator RE1-silencing transcription factor (REST).; Authors - Nathaniel Tate Burkholder ; KD Validated
human	WB	Cell Death Dis; MicroRNA-26a/b have protective roles in oral lichen planus.; Authors - Jie Du
human	WB	Iran J Basic Med Sci; MiR-574-5p promotes cell proliferation by negatively regulating small C-terminal domain phosphatase 1 in esophageal squamous cell carcinoma; Authors - Chunming Zhao
mouse	WB	Cell Mol Neurobiol; Elabela, a Novel Peptide, Exerts Neuroprotective Effects Against Ischemic Stroke Through the APJ/miR-124-3p/CTDSP1/AKT Pathway; Authors - Kang-Long Zhang