CXCL10/IP-10 Rekombinanter Antikörper

CXCL10/IP-10 Rekombinant Antikörper für FC (Intra)

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

FC (Intra)

Konjugation

Unkonjugiert

CloneNo.

242013E12

Kat-Nr. : 98265-1-PBS

Synonyme

CXCL10, CXCL10/IP10, IP10, 10 kDa interferon gamma-induced protein, 242013E12

---

• 

  FC experiment of human PBMCs using 98265-1-RR (same clone as 98265-1-PBS)

  1x10^6 untreated or IFN gamma and brefeldin A treated human PBMCs were intracellularly stained with 0.25 ug Anti-Human CXCL10/IP-10 Rabbit Recombinant Antibody (98265-1-RR, Clone: 242013E12) and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were fixed with 4% PFA and permeabilized with Flow Cytometry Perm Buffer (PF00011-C). This data was developed using the same antibody clone with 98265-1-PBS in a different storage buffer formulation.

---

Geprüfte Anwendungen

Produktinformation

98265-1-PBS bindet in FC (Intra) CXCL10/IP-10 und zeigt Reaktivität mit human

• Getestete Reaktivität: human
• Wirt / Isotyp: Kaninchen / IgG
• Klonalität: Rekombinant
• Typ: Antikörper
• Immunogen: CXCL10/IP-10 fusion protein Eg2489
• Vollständiger Name: chemokine (C-X-C motif) ligand 10
• Berechnetes Molekulargewicht: 11 kDa
• GenBank-Zugangsnummer: BC010954
• Gene symbol: CXCL10
• Gene ID (NCBI): 3627
• Konjugation: Unkonjugiert
• Form: Liquid
• Reinigungsmethode: Protein A purfication
• Lagerungspuffer: PBS only
• Lagerungsbedingungen: Store at -80°C.

Hintergrundinformationen

CXCL10 (also known as IP-10) is a member of the CXC chemokine family which binds to the CXCR3 receptor to exert its biological effects. CXCL10 is a 12-kDa protein and constitutes two internal disulfide cross bridges. The predicted signal peptidase cleavage generates a 10-kDa secreted polypeptide with four conserved cysteine residues in the N-terminal. The CXCL10 gene localizes on chromosome 4 at band q21, a locus associated with an acute monocytic/B-lymphocyte lineage leukemia exhibiting translocation of t (4; 11) (q21; q23). CXCL10 mediates leukocyte trafficking, adaptive immunity, inflammation, haematopoiesis and angiogenesis. Under proinflammatory conditions CXCL10 is secreted from a variety of cells, such as leukocytes, activated neutrophils, eosinophils, monocytes, epithelial cells, endothelial cells, stromal cells (fibroblasts) and keratinocytes in response to IFN-γ.