CXCL2 Polyklonaler Antikörper

CXCL2 Polyklonal Antikörper für WB, ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human, Maus, Ratte

Anwendung

WB, IF, ELISA

Konjugation

Unkonjugiert

Publikationen

4

Kat-Nr. : 26791-1-AP

Synonyme

C X C motif chemokine 2, CINC 2a, CXCL2, Gro beta, GRO beta T, GRO2, GROb, Growth regulated protein beta, HSF, MGSA b, MIP 2a, MIP2, MIP2 alpha, MIP2A, SB 251353, SCYB2

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Galerie der Validierungsdaten

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  WB analysis using 26791-1-AP

  Various lysates were subjected to SDS PAGE followed by western blot with 26791-1-AP (CXCL2 antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours.

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  WB analysis using 26791-1-AP

  human milk was subjected to SDS PAGE followed by western blot with 26791-1-AP (CXCL2 antibody) at dilution of 1:300 incubated at room temperature for 1.5 hours.

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Geprüfte Anwendungen

• Erfolgreiche Detektion in WB: HepG2-Zellen, Mauslungengewebe, Rattenlungengewebe

Empfohlene Verdünnung

• Western Blot (WB): WB : 1:500-1:1000

It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Sample-dependent, check data in validation data gallery

Veröffentlichte Anwendungen

• WB: See 2 publications below
• IF: See 2 publications below

Produktinformation

26791-1-AP bindet in WB, IF, ELISA CXCL2 und zeigt Reaktivität mit human, Maus, Ratten

• Getestete Reaktivität: human, Maus, Ratte
• In Publikationen genannte Reaktivität: Maus
• Wirt / Isotyp: Kaninchen / IgG
• Klonalität: Polyklonal
• Typ: Antikörper
• Immunogen: CXCL2 fusion protein Ag25376
• Vollständiger Name: chemokine (C-X-C motif) ligand 2
• Berechnetes Molekulargewicht: 107 aa, 11 kDa
• Beobachtetes Molekulargewicht: 11 kDa
• GenBank-Zugangsnummer: BC015753
• Gene symbol: CXCL2
• Gene ID (NCBI): 2920
• Konjugation: Unkonjugiert
• Form: Liquid
• Reinigungsmethode: Antigen-Affinitätsreinigung
• Lagerungspuffer: PBS mit 0.02% Natriumazid und 50% Glycerin pH 7.3.
• Lagerungsbedingungen: Bei -20°C lagern. Nach dem Versand ein Jahr lang stabil Aliquotieren ist bei -20^oC Lagerung nicht notwendig. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

CXCL2, also known as macrophage inflammatory protein 2-alpha (MIP2-alpha), is a member of CXC chemokine family that binds to CXC chemokine receptor 2 (CXCR2). CXCL2 is mainly produced by macrophages, endothelial cells, epithelial cells and tumor cells. CXCL2 plays important roles in various biological progresses such as angiogenesis, inflammation, immune response and cancer biological behaviors. Under inflammatory conditions in CNS, microglia and astrocytes may secrete CXCL2 as well as other chemokines, which induces chemotaxis and infiltration of circulatory neutrophils. Indeed, previous studies suggest that CXCL2 is involved in Alzheimer disease, multiple sclerosis and brain ischemia.

Publikationen

Species	Application	Title
mouse	IF	Acta Pharmacol Sin; A novel resveratrol analog upregulates sirtuin 1 and inhibits inflammatory cell infiltration in acute pancreatitis.; Authors - Zheng-Nan Ren
mouse	IF	Int J Mol Sci; MyD88 in Macrophages Enhances Liver Fibrosis by Activation of NLRP3 Inflammasome in HSCs.; Authors - Shuang Ge
mouse	WB	J Immunol; Macrophagic Extracellular Vesicle CXCL2 Recruits and Activates the Neutrophil CXCR2/PKC/NOX4 Axis in Sepsis.; Authors - Guozhen Wang
mouse	WB	Int Immunopharmacol; Isoliquiritigenin alleviates LPS/ D-GalN-induced acute liver failure by activating the PGC-1α/ Nrf2 pathway to reduce oxidative stress and inflammatory response.; Authors - Lu Wang