CXCR6 Rekombinanter Antikörper

CXCR6 Rekombinant Antikörper für IF-P

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

IF-P

Konjugation

APC Fluorescent Dye

CloneNo.

241662E5

Kat-Nr. : APC-84591

Synonyme

CXCR 6, CXC R6, CDw186, CD186, BONZO

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  IF Staining of human tonsillitis using APC-84591

  Immunofluorescent analysis of (4% PFA) fixed paraffin-embedded human tonsillitis tissue using APC CXCR6 antibody (APC-84591, Clone: 241662E5 ) at dilution of 1:200. Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

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  IF Staining of human tonsillitis using APC-84591

  Immunofluorescent analysis of (4% PFA) fixed paraffin-embedded human tonsillitis tissue using APC CXCR6 antibody (APC-84591, Clone: 241662E5 ) at dilution of 1:200. Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

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Geprüfte Anwendungen

• Erfolgreiche Detektion in IF-P: humanes Tonsillitisgewebe

Empfohlene Verdünnung

• Immunfluoreszenz (IF)-P: IF-P : 1:50-1:500

It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Sample-dependent, check data in validation data gallery

Produktinformation

APC-84591 bindet in IF-P CXCR6 und zeigt Reaktivität mit human

• Getestete Reaktivität: human
• Wirt / Isotyp: Kaninchen / IgG
• Klonalität: Rekombinant
• Typ: Antikörper
• Immunogen: Peptid
• Vollständiger Name: chemokine (C-X-C motif) receptor 6
• Berechnetes Molekulargewicht: 39 kDa
• Beobachtetes Molekulargewicht: 45 kDa
• GenBank-Zugangsnummer: BC033584
• Gene symbol: CXCR6
• Gene ID (NCBI): 10663
• Konjugation: APC Fluorescent Dye
• Excitation/Emission maxima wavelengths: 650 nm / 660 nm
• Form: Liquid
• Reinigungsmethode: Protein-A-Reinigung
• Lagerungspuffer: PBS with 0.09% sodium azide and 0.5% BSA
• Lagerungsbedingungen: Store at 2-8°C. Avoid exposure to light. Stable for one year after shipment. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

CXCR6, or C-X-C chemokine receptor 6, is a G protein-coupled receptor with seven transmembrane domains that belong to the CXC chemokine receptor family. This family also includes CXCR1, CXCR2, CXCR3, CXCR4, CXCR5, and CXCR7. CXCR6 is expressed in several T lymphocyte subsets and bone marrow stromal cells. The encoded protein and its exclusive ligand, chemokine ligand 16 (CCL16), are part of a signaling pathway that regulates T lymphocyte migration to various peripheral tissues such as the liver, spleen red pulp, intestine, lungs, and skin. CXCR6 plays a crucial role in immunosurveillance through its interaction with epithelial cells and certain subpopulations of intratumor dendritic cells (DC), particularly DC3, which express CXCL16 at the membrane.