CXorf21 Polyklonaler Antikörper

CXorf21 Polyklonal Antikörper für WB, IHC, IF/ICC, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human, Maus, Ratte

Anwendung

WB, IHC, IF/ICC, Indirect ELISA

Konjugation

Unkonjugiert

Kat-Nr. : 30244-1-PBS

Synonyme

TASL, TLR adapter interacting with SLC15A4 on the lysosome

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  WB analysis using 30244-1-AP (same clone as 30244-1-PBS)

  THP-1 cells were subjected to SDS PAGE followed by western blot with 30244-1-AP (CXorf21 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 30244-1-PBS in a different storage buffer formulation.

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  IHC staining of mouse skin using 30244-1-AP (same clone as 30244-1-PBS)

  Immunohistochemical analysis of paraffin-embedded mouse skin tissue slide using 30244-1-AP (CXorf21 antibody) at dilution of 1:500 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 30244-1-PBS in a different storage buffer formulation.

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  IHC staining of mouse skin using 30244-1-AP (same clone as 30244-1-PBS)

  Immunohistochemical analysis of paraffin-embedded mouse skin tissue slide using 30244-1-AP (CXorf21 antibody) at dilution of 1:500 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 30244-1-PBS in a different storage buffer formulation.

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  IHC staining of rat skin using 30244-1-AP (same clone as 30244-1-PBS)

  Immunohistochemical analysis of paraffin-embedded rat skin tissue slide using 30244-1-AP (CXorf21 antibody) at dilution of 1:500 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 30244-1-PBS in a different storage buffer formulation.

• 

  IHC staining of rat skin using 30244-1-AP (same clone as 30244-1-PBS)

  Immunohistochemical analysis of paraffin-embedded rat skin tissue slide using 30244-1-AP (CXorf21 antibody) at dilution of 1:500 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 30244-1-PBS in a different storage buffer formulation.

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  IHC staining of rat stomach using 30244-1-AP (same clone as 30244-1-PBS)

  Immunohistochemical analysis of paraffin-embedded rat stomach tissue slide using 30244-1-AP (CXorf21 antibody) at dilution of 1:500 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 30244-1-PBS in a different storage buffer formulation.

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  IHC staining of human cervical cancer using 30244-1-AP (same clone as 30244-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human cervical cancer tissue slide using 30244-1-AP (CXorf21 antibody) at dilution of 1:500 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 30244-1-PBS in a different storage buffer formulation.

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  IF Staining of U2OS using 30244-1-AP (same clone as 30244-1-PBS)

  Immunofluorescent analysis of (-20°C Methanol) fixed U2OS cells using CXorf21 antibody (30244-1-AP) at dilution of 1:400 and CoraLite®488-Conjugated AffiniPure Goat Anti-Rabbit IgG(H+L). This data was developed using the same antibody clone with 30244-1-PBS in a different storage buffer formulation.

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  IF Staining of U-251 using 30244-1-AP (same clone as 30244-1-PBS)

  Immunofluorescent analysis of (-20°C Ethanol) fixed U-251 cells using CXorf21 antibody (30244-1-AP) at dilution of 1:200 and CoraLite®488-Conjugated AffiniPure Goat Anti-Rabbit IgG(H+L), CL594-phalloidin (red). This data was developed using the same antibody clone with 30244-1-PBS in a different storage buffer formulation.

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Geprüfte Anwendungen

Produktinformation

30244-1-PBS bindet in WB, IHC, IF/ICC, Indirect ELISA CXorf21 und zeigt Reaktivität mit human, Maus, Ratten

• Getestete Reaktivität: human, Maus, Ratte
• Wirt / Isotyp: Kaninchen / IgG
• Klonalität: Polyklonal
• Typ: Antikörper
• Immunogen: CXorf21 fusion protein Ag32773
• Vollständiger Name: chromosome X open reading frame 21
• Beobachtetes Molekulargewicht: 34 kDa
• GenBank-Zugangsnummer: BC020611
• Gene symbol: CXorf21
• Gene ID (NCBI): 80231
• Konjugation: Unkonjugiert
• Form: Liquid
• Reinigungsmethode: Antigen-Affinitätsreinigung
• Lagerungspuffer: PBS only
• Lagerungsbedingungen: Store at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

CXorf21 (Chromosome X open reading frame 21) is also named as TASL and TLR adapter interacting with SLC15A4 on the lysosome. CXorf21 is an innate immune adapter that mediates the recruitment and activation of IRF5 downstream of endolysosomal toll-like receptors TLR7, TLR8 and TLR9 (PMID:32433612). CXorf21 plays a role in the regulation of endolysosomal pH in immune cells such as B-cells, dendritic cells and monocytes (PMID: 31001245). CXorf21 is a mediator of the X-chromosome gene dose-dependent increased risk of SLE in females (PMID: 31695690).