CYC1 Polyklonaler Antikörper

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• KD/KO Validated

CYC1 Polyklonal Antikörper für WB, IHC, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human, Maus

Anwendung

WB, IHC, Indirect ELISA

Konjugation

Unkonjugiert

Kat-Nr. : 10242-1-PBS

Synonyme

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  WB analysis of human brain using 10242-1-AP (same clone as 10242-1-PBS)

  human brain tissue were subjected to SDS PAGE followed by western blot with 10242-1-AP (CYC1 antibody) at dilution of 1:300 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 10242-1-PBS in a different storage buffer formulation.

• 

  WB analysis of human brain using 10242-1-AP (same clone as 10242-1-PBS)

  human brain tissue were subjected to SDS PAGE followed by western blot with 10242-1-AP (CYC1 antibody) at dilution of 1:300 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 10242-1-PBS in a different storage buffer formulation.

• 

  IHC staining of human liver cancer using 10242-1-AP (same clone as 10242-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human liver cancer tissue slide using 10242-1-AP (CYC1 antibody) at dilution of 1:200 (under 10x lens). This data was developed using the same antibody clone with 10242-1-PBS in a different storage buffer formulation.

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  IHC staining of human liver cancer using 10242-1-AP (same clone as 10242-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human liver cancer tissue slide using 10242-1-AP (CYC1 antibody) at dilution of 1:200 (under 40x lens). This data was developed using the same antibody clone with 10242-1-PBS in a different storage buffer formulation.

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  IHC staining of human breast cancer using 10242-1-AP (same clone as 10242-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human breast cancer using 10242-1-AP (CYC1 antibody) at dilution of 1:100 (under 40x lens). This data was developed using the same antibody clone with 10242-1-PBS in a different storage buffer formulation.

• 

  IHC staining of human breast cancer using 10242-1-AP (same clone as 10242-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human breast cancer using 10242-1-AP (CYC1 antibody) at dilution of 1:100 (under 10x lens). This data was developed using the same antibody clone with 10242-1-PBS in a different storage buffer formulation.

• 

  IHC staining of human breast cancer using 10242-1-AP (same clone as 10242-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human breast cancer using 10242-1-AP (CYC1 antibody) at dilution of 1:50 (under 25x lens). This data was developed using the same antibody clone with 10242-1-PBS in a different storage buffer formulation.

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Geprüfte Anwendungen

Produktinformation

10242-1-PBS bindet in WB, IHC, Indirect ELISA CYC1 und zeigt Reaktivität mit human, Maus

• Getestete Reaktivität: human, Maus
• Wirt / Isotyp: Kaninchen / IgG
• Klonalität: Polyklonal
• Typ: Antikörper
• Immunogen: CYC1 fusion protein Ag0291
• Vollständiger Name: cytochrome c-1
• Berechnetes Molekulargewicht: 35 kDa
• Beobachtetes Molekulargewicht: 35 kDa
• GenBank-Zugangsnummer: BC001006
• Gene symbol: CYC1
• Gene ID (NCBI): 1537
• Konjugation: Unkonjugiert
• Form: Liquid
• Reinigungsmethode: Antigen-Affinitätsreinigung
• Lagerungspuffer: PBS only
• Lagerungsbedingungen: Store at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

CYC1, also named as Cytochrome c-1, belongs to the cytochrome c family. Cytochrome c1 is one respiratory subunit of the 11 subunits of the cytochrome bc1 complex of the mitochondrial electron-transfer chain. It mediates the transfer of an electron from Rieske iron-sulfur protein to cytochrome c(PMID:3036122 ). CYC1 mediates apoptosis. In this pathway, a variety of apoptotic stimuli cause CYC1 release from mitochondria, which in turn induces a series of biochemical reactions that result incaspase activation and subsequent cell death.(PMID:15189137) While CYC1 release and DNA fragmentation are unaffected by the noncleavablep75 mutant, mitochondrial morphology of dying cells is maintained, and loss of plasma membrane integrity is delayed(PMID:15186778). The protein migrated as a 35 kd band in SDS page.

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