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CYP7A1 Rekombinanter Antikörper

CYP7A1 Rekombinant Antikörper für WB, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human, Maus

Anwendung

WB, Indirect ELISA

Konjugation

Unkonjugiert

CloneNo.

250554G10

Kat-Nr. : 86045-2-PBS

Synonyme

Cholesterol 7-alpha-hydroxylase, Cholesterol 7-alpha-monooxygenase, CP7A, CYP7, CYPVII

Filter:
  • Western Blot (WB) analysis of various lysates using CYP7A1 Recombinant monoclonal antibody (86045-2-RR)

    WB analysis using 86045-2-RR (same clone as 86045-2-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 86045-2-RR (CYP7A1 antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 86045-2-PBS in a different storage buffer formulation.

  • Affinity and Kinetic Characterization of 86045-2-RR

    Affinity and Kinetic Characterization of 86045-2-RR

    Biolayer interferometry (BLl) kinetic assays of 86045-2-RR against Human CYP7A1 were performed. The affinity constant is below 1 pM.

Geprüfte Anwendungen

Produktinformation

86045-2-PBS bindet in WB, Indirect ELISA CYP7A1 und zeigt Reaktivität mit human, Maus

Getestete Reaktivität human, Maus
Wirt / Isotyp Kaninchen / IgG
Klonalität Rekombinant
Typ Antikörper
Immunogen CYP7A1 fusion protein Ag12572
Vollständiger Name cytochrome P450, family 7, subfamily A, polypeptide 1
Berechnetes Molekulargewicht 504 aa, 58 kDa
Beobachtetes Molekulargewicht 58 kDa
GenBank-ZugangsnummerBC101777
Gene symbol CYP7A1
Gene ID (NCBI) 1581
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Protein-A-Reinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

CYP7A1 (Cytochrome P450 Family 7 Subfamily A Member 1), is a cholesterol 7alpha-hydroxylase, catalyzing the first and rate-limiting step in the neutral or classic pathway for bile acid biosynthesis. CYP7A1 is a postulated gene modifier of colorectal cancer risk and target for the therapeutic bile acid, ursodeoxycholic acid (UDCA). The CYP7A1 enzyme controls the rate-limiting step of the catabolism of cholesterol into bile acids in the liver.