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Cadherin-11 Polyklonaler Antikörper

Cadherin-11 Polyklonal Antikörper für WB, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

WB, Indirect ELISA

Konjugation

Unkonjugiert

Kat-Nr. : 12028-1-PBS

Synonyme

CDH11, CAD11, Cadherin 11, CDHOB, OB

Filter:
  • Western Blot (WB) analysis of PC-3 cells using Cadherin-11 Polyclonal antibody (12028-1-AP)

    WB analysis of PC-3 using 12028-1-AP (same clone as 12028-1-PBS)

    PC-3 cells were subjected to SDS PAGE followed by western blot with 12028-1-AP (Cadherin-11 antibody) at dilution of 1:300 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 12028-1-PBS in a different storage buffer formulation.

Geprüfte Anwendungen

Produktinformation

12028-1-PBS bindet in WB, Indirect ELISA Cadherin-11 und zeigt Reaktivität mit human

Getestete Reaktivität human
Wirt / Isotyp Kaninchen / IgG
Klonalität Polyklonal
Typ Antikörper
Immunogen Cadherin-11 fusion protein Ag2659
Vollständiger Name cadherin 11, type 2, OB-cadherin (osteoblast)
Berechnetes Molekulargewicht 796 aa, 88 kDa
Beobachtetes Molekulargewicht120 kDa
GenBank-ZugangsnummerBC013609
Gene symbol CDH11
Gene ID (NCBI) 1009
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Antigen-Affinitätsreinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

Cadherins are a family of transmembrane glycoproteins that mediate calcium-dependent cell-cell adhesion and play an important role in the maintenance of normal tissue architecture. Cadherin-11 (CDH11), also known osteoblast cadherin (OB-cadherin) or OSF-4, was identified initially in a mouse osteoblastic cell line and human osteosarcoma (PMID: 8163513). Cadherin-11 is a single pass transmembrane protein consisting of an extracellular domain which contains five repeat sequences (EC1-EC5), a transmembrane segment and a cytoplasmic domain which links catenins to the actin and microtubule cytoskeleton (PMID: 8163513; 33442417). It has been shown that cadherin-11 plays important roles in the occurrence and development of a lot of diseases, arthritis, cancer, aortic calcification disease, dermatosis (PMID: 33442417).