Calsequestrin 2 Polyklonaler Antikörper

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• KD/KO Validated

Calsequestrin 2 Polyklonal Antikörper für WB, IHC, IF/ICC, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

Hausschwein, human, Maus, Ratte

Anwendung

WB, IHC, IF/ICC, Indirect ELISA

Konjugation

Unkonjugiert

Kat-Nr. : 18422-1-PBS

Synonyme

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• 

  WB analysis of human heart using 18422-1-AP (same clone as 18422-1-PBS)

  human heart tissue were subjected to SDS PAGE followed by western blot with 18422-1-AP (Calsequestrin 2 antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 18422-1-PBS in a different storage buffer formulation.

• 

  WB analysis using 18422-1-AP (same clone as 18422-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 18422-1-AP (Calsequestrin 2 antibody) at dilution of 1:8000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 18422-1-PBS in a different storage buffer formulation.

• 

  WB analysis of human skeletal muscle using 18422-1-AP (same clone as 18422-1-PBS)

  human skeletal muscle tissue were subjected to SDS PAGE followed by western blot with 18422-1-AP (Calsequestrin 2 antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 18422-1-PBS in a different storage buffer formulation.

• 

  IHC staining of human heart using 18422-1-AP (same clone as 18422-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human heart tissue slide using 18422-1-AP (Calsequestrin 2 antibody at dilution of 1:200 (under 10x lens). This data was developed using the same antibody clone with 18422-1-PBS in a different storage buffer formulation.

• 

  IHC staining of human heart using 18422-1-AP (same clone as 18422-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human heart tissue slide using 18422-1-AP (Calsequestrin 2 antibody at dilution of 1:200 (under 40x lens). This data was developed using the same antibody clone with 18422-1-PBS in a different storage buffer formulation.

• 

  IHC staining of human skin using 18422-1-AP (same clone as 18422-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human skin using 18422-1-AP (Calsequestrin 2 antibody) at dilution of 1:100 (under 40x lens). This data was developed using the same antibody clone with 18422-1-PBS in a different storage buffer formulation.

• 

  IHC staining of human spleen using 18422-1-AP (same clone as 18422-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human spleen using 18422-1-AP (Calsequestrin 2 antibody) at dilution of 1:100 (under 10x lens). This data was developed using the same antibody clone with 18422-1-PBS in a different storage buffer formulation.

• 

  IHC staining of human spleen using 18422-1-AP (same clone as 18422-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human spleen using 18422-1-AP (Calsequestrin 2 antibody) at dilution of 1:100 (under 40x lens). This data was developed using the same antibody clone with 18422-1-PBS in a different storage buffer formulation.

• 

  IHC staining of human ovary using 18422-1-AP (same clone as 18422-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human ovary using 18422-1-AP (Calsequestrin 2 antibody) at dilution of 1:100 (under 10x lens). This data was developed using the same antibody clone with 18422-1-PBS in a different storage buffer formulation.

• 

  IHC staining of human ovary using 18422-1-AP (same clone as 18422-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human ovary using 18422-1-AP (Calsequestrin 2 antibody) at dilution of 1:100 (under 40x lens). This data was developed using the same antibody clone with 18422-1-PBS in a different storage buffer formulation.

• 

  IHC staining of human kidney using 18422-1-AP (same clone as 18422-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human kidney using 18422-1-AP (Calsequestrin 2 antibody) at dilution of 1:100 (under 10x lens). This data was developed using the same antibody clone with 18422-1-PBS in a different storage buffer formulation.

• 

  IHC staining of human kidney using 18422-1-AP (same clone as 18422-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human kidney using 18422-1-AP (Calsequestrin 2 antibody) at dilution of 1:100 (under 40x lens). This data was developed using the same antibody clone with 18422-1-PBS in a different storage buffer formulation.

• 

  IHC staining of human placenta using 18422-1-AP (same clone as 18422-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human placenta using 18422-1-AP (Calsequestrin 2 antibody) at dilution of 1:100 (under 10x lens). This data was developed using the same antibody clone with 18422-1-PBS in a different storage buffer formulation.

• 

  IHC staining of human placenta using 18422-1-AP (same clone as 18422-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human placenta using 18422-1-AP (Calsequestrin 2 antibody) at dilution of 1:100 (under 40x lens). This data was developed using the same antibody clone with 18422-1-PBS in a different storage buffer formulation.

• 

  IHC staining of human skin using 18422-1-AP (same clone as 18422-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human skin using 18422-1-AP (Calsequestrin 2 antibody) at dilution of 1:100 (under 10x lens). This data was developed using the same antibody clone with 18422-1-PBS in a different storage buffer formulation.

• 

  IF Staining of C2C12 using 18422-1-AP (same clone as 18422-1-PBS)

  Immunofluorescent analysis of (-20℃ Ethanol) fixed C2C12 cell using 18422-1-AP (Calsequestrin 2 antibody) at dilution of 1:50 and Alexa Fluor 488-conjugated AffiniPure Goat Anti-Rabbit IgG(H+L). This data was developed using the same antibody clone with 18422-1-PBS in a different storage buffer formulation.

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Geprüfte Anwendungen

Produktinformation

18422-1-PBS bindet in WB, IHC, IF/ICC, Indirect ELISA Calsequestrin 2 und zeigt Reaktivität mit Hausschwein, human, Maus, Ratten

• Getestete Reaktivität: Hausschwein, human, Maus, Ratte
• Wirt / Isotyp: Kaninchen / IgG
• Klonalität: Polyklonal
• Typ: Antikörper
• Immunogen: Calsequestrin 2 fusion protein Ag13246
• Vollständiger Name: calsequestrin 2 (cardiac muscle)
• Berechnetes Molekulargewicht: 46 kDa
• Beobachtetes Molekulargewicht: 50 kDa
• GenBank-Zugangsnummer: BC022288
• Gene symbol: Calsequestrin 2
• Gene ID (NCBI): 845
• Konjugation: Unkonjugiert
• Form: Liquid
• Reinigungsmethode: Antigen-Affinitätsreinigung
• Lagerungspuffer: PBS only
• Lagerungsbedingungen: Store at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

Calsequestrin (CASQ) is a Ca2+-binding protein present primarily in junctional sarcoplasmic reticulum of skeletal and cardiac muscle; the cardiac form (CASQ2) is encoded by a separate gene. The primary role of CASQ2 is buffering of the sarcoplasmic reticulum Ca2+ ions, but another role for CASQ2 has emerged recently: CASQ2 regulates the open probability of ryanodine receptor 2 (RyR2). Mutations in CASQ2 cause stress-induced polymorphic ventricular tachycardia, also referred to as catecholaminergic polymorphic ventricular tachycardia 2 (CPVT2), a disease characterized by bidirectional ventricular tachycardia that may lead to cardiac arrest.