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Cleaved Caspase 10/P23 Rekombinanter Antikörper

Cleaved Caspase 10/P23 Rekombinant Antikörper für WB, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

WB, Indirect ELISA

Konjugation

Unkonjugiert

CloneNo.

242468G11

Kat-Nr. : 85104-3-PBS

Synonyme

CASP10, Caspase10, 242468G11, Apoptotic protease Mch 4, Apoptotic protease Mch-4

Filter:
  • Western Blot (WB) analysis of Jurkat cells using Cleaved Caspase 10/P23 Recombinant antibody (85104-3-RR)

    WB analysis of Jurkat using 85104-3-RR (same clone as 85104-3-PBS)

    Staurosporine treated Jurkat cells were subjected to SDS PAGE followed by western blot with 85104-3-RR (Cleaved Caspase 10/P23 antibody) at dilution of 1:2000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 85104-3-PBS in a different storage buffer formulation.

Geprüfte Anwendungen

Produktinformation

85104-3-PBS bindet in WB, Indirect ELISA Cleaved Caspase 10/P23 und zeigt Reaktivität mit human

Getestete Reaktivität human
Wirt / Isotyp Kaninchen / IgG
Klonalität Rekombinant
Typ Antikörper
Immunogen Peptid
Vollständiger Name caspase 10, apoptosis-related cysteine peptidase
Berechnetes Molekulargewicht 59 kDa
Beobachtetes Molekulargewicht23 kDa
GenBank-ZugangsnummerBC042844
Gene symbol Caspase 10
Gene ID (NCBI) 843
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Protein A purfication
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

CASP10(Caspase-10) is also named as MCH4 and belongs to the peptidase C14A family. It is recruited to the CD99 and p55 tumor necrosis factor receptor signaling complexes and promoting CD95 (APO1/Fas) apoptosis. It may also play a critical role in PTK7-knockdown-induced apoptosis, downstream of mitochondria(PMID:21103379). This protein can be Cleavage by granzyme B and autocatalytic activity generate two active subunits. Defects in CASP10 are the cause of autoimmune lymphoproliferative syndrome type 2A (ALPS2A)(PMID:16446975), familial non-Hodgkin lymphoma (NHL)(PMID:12010812) and gastric cancer (GASC)(PMID:11973654). This antibody recognize the cleaved caspase 10.