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Caspase 9 Rekombinanter Antikörper

Caspase 9 Rekombinant Antikörper für WB, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

WB, Indirect ELISA

Konjugation

Unkonjugiert

CloneNo.

242452F12

Kat-Nr. : 84949-4-PBS

Synonyme

CASP9, Caspase 9/p35/p10, APAF 3, APAF3, APAF-3

Filter:
  • Western Blot (WB) analysis of various lysates using Caspase 9 Recombinant antibody (84949-4-RR)

    WB analysis using 84949-4-RR (same clone as 84949-4-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 84949-4-RR (Caspase 9 antibody) at dilution of 1:2000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 84949-4-PBS in a different storage buffer formulation.

Geprüfte Anwendungen

Produktinformation

84949-4-PBS bindet in WB, Indirect ELISA Caspase 9 und zeigt Reaktivität mit human

Getestete Reaktivität human
Wirt / Isotyp Kaninchen / IgG
Klonalität Rekombinant
Typ Antikörper
Immunogen Peptid
Vollständiger Name caspase 9, apoptosis-related cysteine peptidase
Berechnetes Molekulargewicht 46 kDa
Beobachtetes Molekulargewicht46 kDa
GenBank-ZugangsnummerBC002452
Gene symbol Caspase 9
Gene ID (NCBI) 842
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Protein-A-Reinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

Caspase 9, apoptosis-related cysteine protease (CASP9, synonyms: MCH6, APAF3, APAF-3, ICE-LAP6, CASPASE-9c)is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme. Caspase 9 is processed by APAF1; this step is thought to be one of the earliest in the caspase activation cascade. 10380-1-AP can recognize the pre- and cleaved- caspase 9. In recent years, the localization of caspase 9 was a focus of interest. Beside its cytoplasmic distribution, a very extensive localization study was done on rat brain tissue, where caspase 9 was found located predominantly in the nucleus and to a lesser extend in the cytoplasm [PMID: 15541731].