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Cathepsin L Monoklonaler Antikörper
Cathepsin L Monoklonal Antikörper für WB, IHC, IF/ICC, Cytometric bead array, Indirect ELISA
Wirt / Isotyp
Maus / IgG2b
Getestete Reaktivität
human
Anwendung
WB, IHC, IF/ICC, Cytometric bead array, Indirect ELISA
Konjugation
Unkonjugiert
CloneNo.
1A12G8
Kat-Nr. : 66914-1-PBS
Synonyme
Geprüfte Anwendungen
Produktinformation
66914-1-PBS bindet in WB, IHC, IF/ICC, Cytometric bead array, Indirect ELISA Cathepsin L und zeigt Reaktivität mit human
| Getestete Reaktivität | human |
| Wirt / Isotyp | Maus / IgG2b |
| Klonalität | Monoklonal |
| Typ | Antikörper |
| Immunogen | Cathepsin L fusion protein Ag27951 |
| Vollständiger Name | cathepsin L1 |
| Berechnetes Molekulargewicht | 38 kDa |
| Beobachtetes Molekulargewicht | 43 kDa |
| GenBank-Zugangsnummer | BC012612 |
| Gene symbol | Cathepsin L |
| Gene ID (NCBI) | 1514 |
| Konjugation | Unkonjugiert |
| Form | Liquid |
| Reinigungsmethode | Protein-A-Reinigung |
| Lagerungspuffer | PBS only |
| Lagerungsbedingungen | Store at -80°C. 20ul Größen enthalten 0,1% BSA. |
Hintergrundinformationen
CTSL1(Cathepsin L1) is also named as CTSL and MEP, belongs to the peptidase C1 family. It is a lysosomal proteinase whose expression is also up-regulated in the skeletal muscle during starvation(PMID:20088826). It plays an intracellular role in normal intestinal epithelial polarization and initiation of neoplasia(PMID:17622569). CTSL1 also improves cardiac function and inhibits cardiac hypertrophy, inflammation, and fibrosis through blocking AKT/GSK3B signaling(PMID:19096818). The full length protein is 38 kDa with a signal peptide, two propeptide and a glycosylation site. It has been detected the 36 kDa, 39 kDa, 29 kDa and 21 kDa in rat gastrocnemius muscle. These forms of cathepsin L could either be attributed to differences in glycosylation or to partial processing of the proenzyme. (PMID:11696001)





















