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Cleaved Caspase 3/P17/P19 Rekombinanter Antikörper

Cleaved Caspase 3/P17/P19 Rekombinant Antikörper für WB, ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human, Maus

Anwendung

WB, ELISA

Konjugation

Unkonjugiert

CloneNo.

230527B2

Kat-Nr. : 82707-13-PBS

Synonyme

CASP3, Caspase3, 230527B2, CASP 3, CASP-3

Filter:
  • Western Blot (WB) analysis of various lysates using Cleaved Caspase 3/P17/P19 Recombinant antibody (82707-13-RR)

    WB analysis using 82707-13-RR (same clone as 82707-13-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 82707-13-RR (Cleaved Caspase 3/P17/P19 antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 82707-13-PBS in a different storage buffer formulation.

Geprüfte Anwendungen

Produktinformation

82707-13-PBS bindet in WB, ELISA Cleaved Caspase 3/P17/P19 und zeigt Reaktivität mit human, Maus

Getestete Reaktivität human, Maus
Wirt / Isotyp Kaninchen / IgG
Klonalität Rekombinant
Typ Antikörper
Immunogen Peptid
Vollständiger Name caspase 3, apoptosis-related cysteine peptidase
Berechnetes Molekulargewicht 32 kDa
Beobachtetes Molekulargewicht17 kDa, 19 kDa
GenBank-ZugangsnummerNM_032991
Gene symbol Caspase 3
Gene ID (NCBI) 836
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Protein A purfication
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

Caspases, a family of endoproteases, are critical players in cell regulatory networks controlling inflammation and cell death. Initiator caspases (caspase-2, -8, -9, -10, -11, and -12) cleave and activate downstream effector caspases (caspase-3, -6, and -7), which in turn execute apoptosis by cleaving targeted cellular proteins. Caspase 3 plays a key role in the activation of sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Caspase 3 can form heterocomplex with other proteins. This antibody can recognize p17 and p19 fragment of Caspase 3. This antibody is specific for cleaved caspase 3, and does not recognize full length caspase-3. The cleaved P17 and P19 fragment might form complex and shows at around 30-35 kDa by western blot (PMID: 25501826).