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Collagen Type I Monoklonaler Antikörper

Collagen Type I Monoklonal Antikörper für WB, Indirect ELISA

Wirt / Isotyp

Maus / IgG1

Getestete Reaktivität

Hausschwein, human, Maus, Ratte

Anwendung

WB, Indirect ELISA

Konjugation

Unkonjugiert

CloneNo.

3D5E8

Kat-Nr. : 66761-1-PBS

Synonyme

COL1, COL1A2, 3D5E8, Alpha-2 type I collagen, col I

Filter:
  • Western Blot (WB) analysis of rat skin tissue using Collagen Type I Monoclonal antibody (66761-1-Ig)

    WB analysis of rat skin using 66761-1-Ig (same clone as 66761-1-PBS)

    rat skin tissue were subjected to SDS PAGE followed by western blot with 66761-1-Ig (Collagen Type I antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 66761-1-PBS in a different storage buffer formulation.

  • Western Blot (WB) analysis of Mouse tail tissue using Collagen Type I Monoclonal antibody (66761-1-Ig)

    WB analysis of Mouse tail using 66761-1-Ig (same clone as 66761-1-PBS)

    Mouse tail tissue were subjected to SDS PAGE followed by western blot with 66761-1-Ig (Collagen Type I antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 66761-1-PBS in a different storage buffer formulation.

  • Western Blot (WB) analysis of pig skin tissue using Collagen Type I Monoclonal antibody (66761-1-Ig)

    WB analysis of pig skin using 66761-1-Ig (same clone as 66761-1-PBS)

    pig skin tissue were subjected to SDS PAGE followed by western blot with 66761-1-Ig (Collagen Type I antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 66761-1-PBS in a different storage buffer formulation.

Geprüfte Anwendungen

Produktinformation

66761-1-PBS bindet in WB, Indirect ELISA Collagen Type I und zeigt Reaktivität mit Hausschwein, human, Maus, Ratten

Getestete Reaktivität Hausschwein, human, Maus, Ratte
Wirt / Isotyp Maus / IgG1
Klonalität Monoklonal
Typ Antikörper
Immunogen Collagen Type I fusion protein Ag6281
Vollständiger Name collagen, type I, alpha 2
Berechnetes Molekulargewicht 1366 aa, 130 kDa
Beobachtetes Molekulargewicht 140 kDa, 70-80 kDa
GenBank-ZugangsnummerBC054498
Gene symbol COL1A2
Gene ID (NCBI) 1278
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Protein-G-Reinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

Type I collagen, the major structural component of connective tissues such as skin, tendon and bone, is the most abundant and widely expressed collagen in humans (PMID: 7620364; 8645190; 9016532). Type I collagen is a heterotrimer comprising one alpha 2(I) and two alpha 1(I) chains which are encoded by the unlinked loci COL1A2 and COL1A1 respectively. Type I collagen has a molecular mass of about 250-300 kDa, while the alpha 2(I) chain has a molecular weight of about 100-140 kDa. Mutations in COL1A2 gene are associated with osteogenesis imperfecta, Ehlers-Danlos syndrome, idiopathic osteoporosis, and atypical Marfan syndrome. When MMPs degrade type I collagen, the major degradation products are the typical ¾ and ¼ collagen fragments with molecular weights of ~ 50-70 kDa, and ~ 25 (PMID: 8910479).