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Complement factor H Rekombinanter Antikörper

Complement factor H Rekombinant Antikörper für WB, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

WB, Indirect ELISA

Konjugation

Unkonjugiert

CloneNo.

242740E8

Kat-Nr. : 85132-2-PBS

Synonyme

CFH, ARMD4, ARMS1, Factor H, FH

Filter:
  • Western Blot (WB) analysis of human plasma using Complement factor H Recombinant antibody (85132-2-RR)

    WB analysis of human plasma using 85132-2-RR (same clone as 85132-2-PBS)

    human plasma were subjected to SDS PAGE followed by western blot with 85132-2-RR (Complement factor H/CFH antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 85132-2-PBS in a different storage buffer formulation.

Geprüfte Anwendungen

Produktinformation

85132-2-PBS bindet in WB, Indirect ELISA Complement factor H und zeigt Reaktivität mit human

Getestete Reaktivität human
Wirt / Isotyp Kaninchen / IgG
Klonalität Rekombinant
Typ Antikörper
Immunogen Complement factor H fusion protein Eg3753
Vollständiger Name complement factor H
Berechnetes Molekulargewicht139kDa
Beobachtetes Molekulargewicht140-150 kDa
Gene symbol Complement factor H
Gene ID (NCBI) 3075
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Protein-A-Reinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

Complement factor H (CFH) is an abundant plasma glycoprotein that regulates the function of the alternative complement pathway in the fluid phase and on cellular surfaces (PMID: 2963625). Factor H binds to C3b, accelerates the decay of the alternative pathway C3-convertase (C3bBb), and acts as a cofactor for the factor I-mediated proteolytic inactivation of C3b (PMID: 15163532). It plays a critical role in the homeostasis of the complement system in plasma and in the protection of bystander host cells and tissues from damage by complement activation. Abnormalities in factor H have been associated with renal disease (PMID: 18190458).