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Cubilin Polyklonaler Antikörper

Cubilin Polyklonal Antikörper für WB, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human, Maus

Anwendung

WB, Indirect ELISA

Konjugation

Unkonjugiert

Kat-Nr. : 31992-1-PBS

Synonyme

Intrinsic factor-vitamin B12 receptor, Intrinsic factor-cobalamin receptor, Intestinal intrinsic factor receptor, IFCR, CUBN

Filter:
  • Western Blot (WB) analysis of various lysates using Cubilin Polyclonal antibody (31992-1-AP)

    WB analysis using 31992-1-AP (same clone as 31992-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 31992-1-AP (CUBN antibody) at dilution of 1:800 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 31992-1-PBS in a different storage buffer formulation.

Geprüfte Anwendungen

Produktinformation

31992-1-PBS bindet in WB, Indirect ELISA Cubilin und zeigt Reaktivität mit human, Maus

Getestete Reaktivität human, Maus
Wirt / Isotyp Kaninchen / IgG
Klonalität Polyklonal
Typ Antikörper
Immunogen Cubilin fusion protein Ag35808
Vollständiger Name cubilin (intrinsic factor-cobalamin receptor)
Berechnetes Molekulargewicht398kDa
Beobachtetes Molekulargewicht450 kDa
GenBank-ZugangsnummerNM_001081
Gene symbol CUBN
Gene ID (NCBI) 8029
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Antigen-Affinitätsreinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

Cubilin (CUBN) acts as a receptor for intrinsic factor-vitamin B12 complexes. Cubulin is located within the epithelium of intestine and kidney. Mutations in CUBN may play a role in autosomal recessive megaloblastic anemia. Cubilin is an endocytic receptor which plays a role in lipoprotein, vitamin and iron metabolism by facilitating their uptake (PMID: 9572993). Cubilin Acts together with LRP2 to mediate endocytosis of high-density lipoproteins, GC, hemoglobin, ALB, TF and SCGB1A1, which also acts together with AMN to mediate endocytosis of the CBLIF-cobalamin complex (PMID: 14576052). There are multiple glycosylation sites on Cubilin.