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Cyclin D1 Monoklonaler Antikörper
Cyclin D1 Monoklonal Antikörper für WB, FC (Intra), ELISA
Wirt / Isotyp
Maus / IgG2b
Getestete Reaktivität
human, Maus, Ratte
Anwendung
WB, FC (Intra), ELISA
Konjugation
Unkonjugiert
CloneNo.
2G3G5
Kat-Nr. : 60186-1-PBS
Synonyme
Geprüfte Anwendungen
Produktinformation
60186-1-PBS bindet in WB, FC (Intra), ELISA Cyclin D1 und zeigt Reaktivität mit human, Maus, Ratten
Getestete Reaktivität | human, Maus, Ratte |
Wirt / Isotyp | Maus / IgG2b |
Klonalität | Monoklonal |
Typ | Antikörper |
Immunogen | Cyclin D1 fusion protein Ag0689 |
Vollständiger Name | cyclin D1 |
Berechnetes Molekulargewicht | 295 aa, 34 kDa |
Beobachtetes Molekulargewicht | 34 kDa |
GenBank-Zugangsnummer | BC000076 |
Gene symbol | Cyclin D1 |
Gene ID (NCBI) | 595 |
Konjugation | Unkonjugiert |
Form | Liquid |
Reinigungsmethode | Protein-A-Reinigung |
Lagerungspuffer | PBS only |
Lagerungsbedingungen | Store at -80°C. 20ul Größen enthalten 0,1% BSA. |
Hintergrundinformationen
CCND1 (cyclin D1), also known as PRAD1 or BCL1, belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. CCND1 forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. The CCND1 gene, located on 11q13 has been reported to be overexpressed in mantle cell lymphoma (MCL) due to the chromosomal translocation. CCND1 has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Over-expression of CCND1 is known to correlate with the early onset of cancer and risk of tumor progression and metastasis.