DC-SIGNR/CD299 Rekombinanter Antikörper

DC-SIGNR/CD299 Rekombinant Antikörper für FC

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

FC

Konjugation

Biotin

CloneNo.

241683G8

Kat-Nr. : Biotin-FcA98205

Synonyme

CLEC4M, CD209 antigen like protein 1, CD209 antigen-like protein 1, CD209L, CD209L1

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  FC experiment of Transfected HEK-293T using Biotin-FcA98205

  1x10^6 untransfected (left) or CD299-transfected HEK-293T (right) cells were surface stained with 0.25 ug Biotin Anti-Human DC-SIGNR/CD299 Rabbit RecAb (Biotin-FcA98205, Clone: 241683G8) or FcZero-rAb™ Biotin Rabbit IgG Isotype Control Recombinant Antibody (Biotin-FcA98136, Clone: 240953C9), and PE Streptavidin (Cat.No. PF00021). Cells were not fixed.

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  FC experiment of Transfected HEK-293T using Biotin-FcA98205

  1x10^6 untransfected (left) or CD299-transfected HEK-293T (right) cells were surface stained with 0.25 ug Biotin Anti-Human DC-SIGNR/CD299 Rabbit RecAb (Biotin-FcA98205, Clone: 241683G8) (red) or FcZero-rAb™ Biotin Rabbit IgG Isotype Control Recombinant Antibody (Biotin-FcA98136, Clone: 240953C9) (blue), and PE Streptavidin (Cat.No. PF00021). Cells were not fixed.

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Geprüfte Anwendungen

• Erfolgreiche Detektion in FC: Transfected HEK-293T cells

Empfohlene Verdünnung

Anwendung	Verdünnung
This reagent has been tested for flow cytometric analysis. It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, check data in validation data gallery

Produktinformation

Biotin-FcA98205 bindet in FC DC-SIGNR/CD299 und zeigt Reaktivität mit human

• Getestete Reaktivität: human
• Wirt / Isotyp: Kaninchen / IgG
• Klonalität: Rekombinant
• Typ: Antikörper
• Immunogen: Rekombinantes Protein
• Vollständiger Name: C-type lectin domain family 4, member M
• Berechnetes Molekulargewicht: 45 kDa
• GenBank-Zugangsnummer: BC038851
• Gene symbol: DC-SIGNR/CD299
• Gene ID (NCBI): 10332
• Konjugation: Biotin
• Excitation/Emission maxima wavelengths: -
• Form: Liquid
• Reinigungsmethode: Protein-A-Reinigung
• Lagerungspuffer: PBS with 0.09% sodium azide and 0.5% BSA
• Lagerungsbedingungen: Store at 2-8°C. Avoid exposure to light. Stable for one year after shipment.

Hintergrundinformationen

Dendritic cell-specific intracellular adhesion molecule-3-grabbing non-integrin (DC-SIGN/CD209) and DC-SIGN related (DC-SIGNR/CD299/L-SIGN/CD209L/CLEC4M) are trans-membrane C-type lectins that are calcium-dependent carbohydrate-binding proteins, which can act as cell-adhesion and pathogen-recognition receptors (PMID: 18458800). DC-SIGN and DC-SIGNR share 77% amino acid identity (PMID: 10975799; 11226297). DC-SIGN is expressed on subsets of dendritic cells and macrophages while DC-SIGNR is restricted to endothelial cells of the liver, lymph nodes and placenta (PMID: 17509452). DC-SIGNR servers as a receptor for ICAM-3. It recognizes a wide range of evolutionarily divergent pathogens.