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DCC-Specific Polyklonaler Antikörper

DCC-Specific Polyklonal Antikörper für WB, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human, Maus, Ratte

Anwendung

WB, Indirect ELISA

Konjugation

Unkonjugiert

Kat-Nr. : 19123-1-PBS

Synonyme

DCC, Colorectal cancer suppressor, CRC18, CRCR1, IGDCC1

Filter:
  • Western Blot (WB) analysis of mouse brain tissue using DCC-Specific Polyclonal antibody (19123-1-AP)

    WB analysis of mouse brain using 19123-1-AP (same clone as 19123-1-PBS)

    mouse brain tissue were subjected to SDS PAGE followed by western blot with 19123-1-AP (DCC-Specific Antibody) at dilution of 1:600 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 19123-1-PBS in a different storage buffer formulation.

  • Western Blot (WB) analysis of A-673 cells using DCC-Specific Polyclonal antibody (19123-1-AP)

    WB analysis of A-673 using 19123-1-AP (same clone as 19123-1-PBS)

    A-673 cells were subjected to SDS PAGE followed by western blot with 19123-1-AP (DCC-Specific antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 19123-1-PBS in a different storage buffer formulation.

Geprüfte Anwendungen

Produktinformation

19123-1-PBS bindet in WB, Indirect ELISA DCC-Specific und zeigt Reaktivität mit human, Maus, Ratten

Getestete Reaktivität human, Maus, Ratte
Wirt / Isotyp Kaninchen / IgG
Klonalität Polyklonal
Typ Antikörper
Immunogen Peptid
Vollständiger Name deleted in colorectal carcinoma
Berechnetes Molekulargewicht 1447 aa, 158 kDa
Beobachtetes Molekulargewicht 180 kDa
GenBank-ZugangsnummerNM_005215
Gene symbol DCC
Gene ID (NCBI) 1630
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Antigen-Affinitätsreinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

DCC, also named as IGDCC1, belongs to the immunoglobulin superfamily and DCC family. DCC is a receptor for netrin required for axon guidance. DCC mediates axon attraction of neuronal growth cones in the developing nervous system upon ligand binding. Its association with UNC5 proteins may trigger signaling for axon repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. DCC gene is a tumor suppressor gene. This antibody raised against a synthesized polypeptide of human DCC protein recognizes endogenous DCC with an apparent molecular weight of 180 kDa. As the predicted molecular mass of DCC is 158 kDa, the slower mobility is likely attributable to post-translational modification, perhaps by glycosylation at potential N-linked glycosylation sites (PMID: 7926722; 8044801).