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DCC-Specific Monoklonaler Antikörper

DCC-Specific Monoklonal Antikörper für WB, Indirect ELISA

Wirt / Isotyp

Maus / IgG2a

Getestete Reaktivität

human, Maus

Anwendung

WB, Indirect ELISA

Konjugation

Unkonjugiert

CloneNo.

2G4G4

Kat-Nr. : 67203-1-PBS

Synonyme

Colorectal cancer suppressor, CRC18, CRCR1, DCC, DCC-Specific, IGDCC1, Netrin receptor DCC, Tumor suppressor protein DCC

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  • Western Blot (WB) analysis of mouse brain tissue using DCC-Specific Monoclonal antibody (67203-1-Ig)

    WB analysis of mouse brain using 67203-1-Ig (same clone as 67203-1-PBS)

    mouse brain tissue were subjected to SDS PAGE followed by western blot with 67203-1-Ig (DCC-Specific antibody) at dilution of 1:2000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 67203-1-PBS in a different storage buffer formulation.

Geprüfte Anwendungen

Produktinformation

67203-1-PBS bindet in WB, Indirect ELISA DCC-Specific und zeigt Reaktivität mit human, Maus

Getestete Reaktivität human, Maus
Wirt / Isotyp Maus / IgG2a
Klonalität Monoklonal
Typ Antikörper
Immunogen DCC-Specific fusion protein Ag20569
Vollständiger Name deleted in colorectal carcinoma
Berechnetes Molekulargewicht 1447 aa, 158 kDa
Beobachtetes Molekulargewicht 180 kDa
GenBank-ZugangsnummerNM_005215
Gene symbol DCC
Gene ID (NCBI) 1630
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Protein-A-Reinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

DCC, also named as IGDCC1, belongs to the immunoglobulin superfamily and DCC family. DCC is a receptor for netrin required for axon guidance. DCC plays a key role in the developing nervous system. Its association with UNC5 proteins may trigger signaling for axon repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. DCC gene is a tumor suppressor gene. This antibody recognizes endogenous DCC with an apparent molecular weight of 180 kDa. As the predicted molecular mass of DCC is 158 kDa, the slower mobility is likely attributable to post-translational modification, perhaps by glycosylation at potential N-linked glycosylation sites (PMID: 7926722; 8044801).