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DCLRE1B Polyklonaler Antikörper

DCLRE1B Polyklonal Antikörper für WB, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human, Maus, Ratte

Anwendung

WB, Indirect ELISA

Konjugation

Unkonjugiert

Kat-Nr. : 13203-1-PBS

Synonyme

5 exonuclease Apollo, 5' exonuclease Apollo, APOLLO, Beta-lactamase DCLRE1B, DNA cross-link repair 1B protein

Filter:
  • Western Blot (WB) analysis of Jurkat cells using DCLRE1B Polyclonal antibody (13203-1-AP)

    WB analysis of Jurkat using 13203-1-AP (same clone as 13203-1-PBS)

    Jurkat cells were subjected to SDS PAGE followed by western blot with 13203-1-AP (DCLRE1B antibody) at dilution of 1:800 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 13203-1-PBS in a different storage buffer formulation.

  • Western Blot (WB) analysis of HepG2 cells using DCLRE1B Polyclonal antibody (13203-1-AP)

    WB analysis of HepG2 using 13203-1-AP (same clone as 13203-1-PBS)

    HepG2 cells were subjected to SDS PAGE followed by western blot with 13203-1-AP (DCLRE1B Antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 13203-1-PBS in a different storage buffer formulation.

Geprüfte Anwendungen

Produktinformation

13203-1-PBS bindet in WB, Indirect ELISA DCLRE1B und zeigt Reaktivität mit human, Maus, Ratten

Getestete Reaktivität human, Maus, Ratte
Wirt / Isotyp Kaninchen / IgG
Klonalität Polyklonal
Typ Antikörper
Immunogen DCLRE1B fusion protein Ag3945
Vollständiger Name DNA cross-link repair 1B (PSO2 homolog, S. cerevisiae)
Berechnetes Molekulargewicht 532 aa, 60 kDa
Beobachtetes Molekulargewicht 60 kDa
GenBank-ZugangsnummerBC029687
Gene symbol DCLRE1B
Gene ID (NCBI) 64858
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Antigen-Affinitätsreinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

Interstrand cross-links (ICLs) is an extremely cytotoxic form of DNA damage that covalently tethers the two strands of the double helix, which inhibits fundamental nuclear functions, including transcription and DNA replication [PMID:21701511]. DCLRE1B is one of several evolutionarily conserved genes involved in repair of interstrand cross-links [PMID:10848582]. Furthermore, DCLRE1B was identified as a TRF2-interacting protein and, has a role in telomere maintenance in association with the Shelterin complex, preventing non-homologous end-joining-mediated chromosome fusions protecting leading strand telomeres [PMID:20619712].