DDR1 Polyklonaler Antikörper

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• KD/KO Validated

DDR1 Polyklonal Antikörper für IHC, ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human und mehr (1)

Anwendung

IHC, IF, CoIP, ELISA

Konjugation

Unkonjugiert

Publikationen(4)

Kat-Nr. : 10536-1-AP

Synonyme

DDR, Cell adhesion kinase, CD167a, CD167 antigen-like family member A, CD167

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  IHC staining of human colon cancer using 10536-1-AP

  Immunohistochemical analysis of paraffin-embedded human colon cancer tissue slide using 10536-1-AP (DDR1 antibody) at dilution of 1:500 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

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  IHC staining of human colon cancer using 10536-1-AP

  Immunohistochemical analysis of paraffin-embedded human colon cancer tissue slide using 10536-1-AP (DDR1 antibody) at dilution of 1:500 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

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  IHC staining of human testis using 10536-1-AP

  Immunohistochemical analysis of paraffin-embedded human testis tissue slide using 10536-1-AP (DDR1 Antibody) at dilution of 1:200 (under 10x lens).

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  IHC staining of human testis using 10536-1-AP

  Immunohistochemical analysis of paraffin-embedded human testis tissue slide using 10536-1-AP (DDR1 Antibody) at dilution of 1:200 (under 40x lens).

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  IHC staining of human stomach using 10536-1-AP

  Immunohistochemical analysis of paraffin-embedded human stomach tissue slide using 10536-1-AP (DDR1 antibody) at dilution of 1:400 (under 20x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

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  IHC staining of human kidney using 10536-1-AP

  Immunohistochemical analysis of paraffin-embedded human kidney tissue slide using 10536-1-AP (DDR1 Antibody) at dilution of 1:200 (under 10x lens).

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  IHC staining of human kidney using 10536-1-AP

  Immunohistochemical analysis of paraffin-embedded human kidney tissue slide using 10536-1-AP (DDR1 Antibody) at dilution of 1:200 (under 40x lens).

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Geprüfte Anwendungen

• Erfolgreiche Detektion in IHC: humanes Kolonkarzinomgewebe, humanes Nierengewebe, humanes Magengewebe, humanes Hodengewebe; Hinweis: Antigendemaskierung mit TE-Puffer pH 9,0 empfohlen. (*) Wahlweise kann die Antigendemaskierung auch mit Citratpuffer pH 6,0 erfolgen.

Empfohlene Verdünnung

• Immunhistochemie (IHC): IHC : 1:250-1:1000

It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Sample-dependent, check data in validation data gallery

Veröffentlichte Anwendungen

• KD/KO: See 2 publications below
• IHC: See 2 publications below
• IF: See 2 publications below
• CoIP: See 1 publications below

Produktinformation

10536-1-AP bindet in IHC, IF, CoIP, ELISA DDR1 und zeigt Reaktivität mit human

• Getestete Reaktivität: human
• In Publikationen genannte Reaktivität: human, Maus
• Wirt / Isotyp: Kaninchen / IgG
• Klonalität: Polyklonal
• Typ: Antikörper
• Immunogen: DDR1 fusion protein Ag0794
• Vollständiger Name: discoidin domain receptor tyrosine kinase 1
• Berechnetes Molekulargewicht: 97 kDa
• GenBank-Zugangsnummer: BC008716
• Gene symbol: DDR1
• Gene ID (NCBI): 780
• Konjugation: Unkonjugiert
• Form: Liquid
• Reinigungsmethode: Antigen-Affinitätsreinigung
• Lagerungspuffer: PBS with 0.02% sodium azide and 50% glycerol
• Lagerungsbedingungen: Bei -20°C lagern. Nach dem Versand ein Jahr lang stabil Aliquotieren ist bei -20^oC Lagerung nicht notwendig. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

DDR1, or Discoidin Domain Receptor 1, is a member of the receptor tyrosine kinase (RTK) family, which plays a significant role in various cellular processes including cell proliferation, adhesion, migration, and extracellular matrix (ECM) remodeling. DDR1 is known for its unique discoidin domain that allows it to bind specifically to certain collagens, initiating downstream signaling pathways that can lead to cell transformation and tumor progression. Abnormal activation of DDR1 is closely associated with the development of various solid tumors, and it has been shown that DDR1 can prevent immune cells from infiltrating triple-negative breast cancer (TNBC) and eliminate tumor cells.

Publikationen

Species	Application	Title
human,mouse	IF,CoIP	Nat Commun; Endothelial discoidin domain receptor 1 senses flow to modulate YAP activation; Authors - Jiayu Liu ; KD Validated
human	IHC,IF	Bioact Mater; Matrix stiffness exacerbates the proinflammatory responses of vascular smooth muscle cell through the DDR1-DNMT1 mechanotransduction axis.; Authors - Jin Wang ; KD Validated
human	IHC	J Exp Clin Cancer Res; High expression of DDR1 is associated with the poor prognosis in Chinese patients with pancreatic ductal adenocarcinoma.; Authors - Yanmiao Huo
human		Exp Cell Res; Downregulation of CYRI-B promotes migration, invasion and EMT by activating the Rac1-STAT3 pathway in gastric cancer; Authors - Guangyao Liu

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