DDR1/CD167a Rekombinanter Antikörper

DDR1/CD167a Rekombinant Antikörper für WB, IHC, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

WB, IHC, Indirect ELISA

Konjugation

Unkonjugiert

CloneNo.

241796D10

Kat-Nr. : 84438-6-PBS

Synonyme

DDR1, 241796D10, CAK, CD167, CD167 antigen-like family member A

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  WB analysis using 84438-6-RR (same clone as 84438-6-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 84438-6-RR (DDR1 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 84438-6-PBS in a different storage buffer formulation.

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  IHC staining of mouse brain using 84438-6-RR (same clone as 84438-6-PBS)

  Immunohistochemical analysis of paraffin-embedded mouse brain tissue slide using 84438-6-RR (DDR1 antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 84438-6-PBS in a different storage buffer formulation.

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Geprüfte Anwendungen

Produktinformation

84438-6-PBS bindet in WB, IHC, Indirect ELISA DDR1/CD167a und zeigt Reaktivität mit human

• Getestete Reaktivität: human
• Wirt / Isotyp: Kaninchen / IgG
• Klonalität: Rekombinant
• Typ: Antikörper
• Immunogen: DDR1/CD167a fusion protein Eg1675
• Vollständiger Name: discoidin domain receptor tyrosine kinase 1
• Berechnetes Molekulargewicht: 101 kDa
• Beobachtetes Molekulargewicht: 120 kDa
• GenBank-Zugangsnummer: NM_001297654
• Gene symbol: DDR1
• Gene ID (NCBI): 780
• Konjugation: Unkonjugiert
• Form: Liquid
• Reinigungsmethode: Protein A purfication
• Lagerungspuffer: PBS only
• Lagerungsbedingungen: Store at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

DDR1, or Discoidin Domain Receptor 1, is a member of the receptor tyrosine kinase (RTK) family, which plays a significant role in various cellular processes including cell proliferation, adhesion, migration, and extracellular matrix (ECM) remodeling. DDR1 is known for its unique discoidin domain that allows it to bind specifically to certain collagens, initiating downstream signaling pathways that can lead to cell transformation and tumor progression. Abnormal activation of DDR1 is closely associated with the development of various solid tumors, and it has been shown that DDR1 can prevent immune cells from infiltrating triple-negative breast cancer (TNBC) and eliminate tumor cells.