DEFB119 Polyklonaler Antikörper

DEFB119 Polyklonal Antikörper für WB, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

WB, Indirect ELISA

Konjugation

Unkonjugiert

Kat-Nr. : 33236-1-PBS

Synonyme

Beta-defensin 119, Beta-defensin 120, Beta-defensin 19, Beta-defensin 20, DEFB120

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  WB analysis using 33236-1-AP (same clone as 33236-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 33236-1-AP (DEFB119 antibody) at dilution of 1:3000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 33236-1-PBS in a different storage buffer formulation.

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Geprüfte Anwendungen

Produktinformation

33236-1-PBS bindet in WB, Indirect ELISA DEFB119 und zeigt Reaktivität mit human

• Getestete Reaktivität: human
• Wirt / Isotyp: Kaninchen / IgG
• Klonalität: Polyklonal
• Typ: Antikörper
• Immunogen: DEFB119 fusion protein Ag36816
• Vollständiger Name: defensin, beta 119
• Berechnetes Molekulargewicht: 84 aa, 10 kDa
• Beobachtetes Molekulargewicht: 10 kDa
• GenBank-Zugangsnummer: BC062212
• Gene symbol: DEFB119
• Gene ID (NCBI): 245932
• Konjugation: Unkonjugiert
• Form: Liquid
• Reinigungsmethode: Antigen-Affinitätsreinigung
• Lagerungspuffer: PBS only
• Lagerungsbedingungen: Store at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

DEFB119 is a reproductive tract-specific β-defensin highly expressed in the testis and the epididymis (16). Single-cell sequencing analysis of testicular cells isolated from nonobstructive azoospermia men demonstrates an elevated expression of DEFB119 in the Sertoli cells. Male mice lacking the mouse ortholog DEFB19 demonstrated subfertility in both sexes. DEFB119 is also expressed in sperm and is involved in sperm chemotaxis. Elevated seminal DEFB119 was associated with a decrease in the observed genera, diversity and evenness of bacterial communities, and further distortion of the metacommunities (PMID: 39359400).