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DIRAS2 Rekombinanter Antikörper

DIRAS2 Rekombinant Antikörper für WB, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human, Maus, Ratte

Anwendung

WB, Indirect ELISA

Konjugation

Unkonjugiert

CloneNo.

251286F3

Kat-Nr. : 86460-1-PBS

Synonyme

GTP binding protein Di Ras2, GTP-binding protein Di-Ras2

Filter:
  • Western Blot (WB) analysis of various lysates using DIRAS2 Recombinant monoclonal antibody (86460-1-RR)

    WB analysis using 86460-1-RR (same clone as 86460-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 86460-1-RR (DIRAS2 antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 86460-1-PBS in a different storage buffer formulation.

Geprüfte Anwendungen

Produktinformation

86460-1-PBS bindet in WB, Indirect ELISA DIRAS2 und zeigt Reaktivität mit human, Maus, Ratten

Getestete Reaktivität human, Maus, Ratte
Wirt / Isotyp Kaninchen / IgG
Klonalität Rekombinant
Typ Antikörper
Immunogen DIRAS2 fusion protein Ag7926
Vollständiger Name DIRAS family, GTP-binding RAS-like 2
Berechnetes Molekulargewicht 22 kDa
Beobachtetes Molekulargewicht 22 kDa
GenBank-ZugangsnummerBC008065
Gene symbol DIRAS2
Gene ID (NCBI) 54769
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Protein-A-Reinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

GTP-binding protein Di-Ras2 (DIRAS2) is a member of the Ras-related small G-protein family. DIRAS2 regulated the phosphorylation of downstream effector proteins and activated the RAS/mitogen-activated protein kinase (MAPK) signaling pathway (PMID: 3216131). DIRAS2 interacted with 26S proteasome non-ATPase regulatory subunit 2, which facilitates the degradation of DIRAS2 in a proteasome-mediated way. DIRAS2 blocked nuclear factor kappa light-chain enhancer of activated B-cell (NF-κB) signaling pathways, inducing G0/G1 arrest. DIRAS2 inhibited CRC cell proliferation and affected cell-cycle protein expression (PMID: 35173535). DIRAS2 was proved to be an oncogene that activated the RAS-MAPK pathway to induce cell proliferation and metastasis in renal cell cancer (PMID: 3216131). DIRAS2 also shows its activity as a tumor-suppressor gene to induce autophagic cell death via modulating nuclear localization FOXO3/FOXO3A and TFEB (PMID: 29368982).