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DLK1 Polyklonaler Antikörper

DLK1 Polyklonal Antikörper für WB, IHC, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human, Maus, Ratte

Anwendung

WB, IHC, Indirect ELISA

Konjugation

Unkonjugiert

Kat-Nr. : 29288-1-PBS

Synonyme

Filter:
  • Western Blot (WB) analysis of various lysates using DLK1 Polyclonal antibody (29288-1-AP)

    WB analysis using 29288-1-AP (same clone as 29288-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 29288-1-AP (DLK1 antibody) at dilution of 1:1500 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 29288-1-PBS in a different storage buffer formulation.

  • Immunohistochemistry (IHC) staining of human placenta tissue using DLK1 Polyclonal antibody (29288-1-AP)

    IHC staining of human placenta using 29288-1-AP (same clone as 29288-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human placenta tissue slide using 29288-1-AP (DLK1 antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 29288-1-PBS in a different storage buffer formulation.

  • Immunohistochemistry (IHC) staining of human placenta tissue using DLK1 Polyclonal antibody (29288-1-AP)

    IHC staining of human placenta using 29288-1-AP (same clone as 29288-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human placenta tissue slide using 29288-1-AP (DLK1 antibody) at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 29288-1-PBS in a different storage buffer formulation.

Geprüfte Anwendungen

Produktinformation

29288-1-PBS bindet in WB, IHC, Indirect ELISA DLK1 und zeigt Reaktivität mit human, Maus, Ratten

Getestete Reaktivität human, Maus, Ratte
Wirt / Isotyp Kaninchen / IgG
Klonalität Polyklonal
Typ Antikörper
Immunogen DLK1 fusion protein Ag30916
Vollständiger Name delta-like 1 homolog (Drosophila)
Berechnetes Molekulargewicht 41 kDa
Beobachtetes Molekulargewicht60 kDa
GenBank-ZugangsnummerBC007741
Gene symbol DLK1
Gene ID (NCBI) 8788
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Antigen-Affinitätsreinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

DLK1, also named PREF1, FA1, or pG2, is a transmembrane protein belonging to the epidermal growth factor (EGF)-like superfamily (PMID: 8095043). It contains six EGF-like repeats in the extracellular region. DLK1 is abundant in preadipocytes and regulate adipocyte differentiation negatively (PMID: 8500166). Deficiency of DLK1 gives rise to growth retardation and accelerated adiposity in mouse model. Expression of DLK1 is found in tumors with neuroendocrine features that implies DLK1 may be involved in neuroendocrine differentiation (PMID: 8095043). It has been reported overexpression of DLK1 could lead to the development of metabolic abnormalities by impairment of adipocyte function in mice (PMID: 12588883). The gene of DLK1 maps to chromosome 14q32, and encodes a 383-amino acid protein with a calculated molecular mass of 41 kDa. In preadipocytes, multiple discrete forms of DLK1 protein of 45-60 kDa are present, owing in part to N-linked glycosylation (PMID: 8500166).