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DLL1 Polyklonaler Antikörper

DLL1 Polyklonal Antikörper für WB, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human, Maus, Ratte

Anwendung

WB, Indirect ELISA

Konjugation

Unkonjugiert

Kat-Nr. : 28544-1-PBS

Synonyme

Filter:
  • Western Blot (WB) analysis of various lysates using DLL1 Polyclonal antibody (28544-1-AP)

    WB analysis using 28544-1-AP (same clone as 28544-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 28544-1-AP (DLL1 antibody) at dilution of 1:2500 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 28544-1-PBS in a different storage buffer formulation.

  • Western Blot (WB) analysis of various lysates using DLL1 Polyclonal antibody (28544-1-AP)

    WB analysis using 28544-1-AP (same clone as 28544-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 28544-1-AP (DLL1 antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 28544-1-PBS in a different storage buffer formulation.

Geprüfte Anwendungen

Produktinformation

28544-1-PBS bindet in WB, Indirect ELISA DLL1 und zeigt Reaktivität mit human, Maus, Ratten

Getestete Reaktivität human, Maus, Ratte
Wirt / Isotyp Kaninchen / IgG
Klonalität Polyklonal
Typ Antikörper
Immunogen DLL1 fusion protein Ag29534
Vollständiger Name delta-like 1 (Drosophila)
Berechnetes Molekulargewicht 78 kDa
Beobachtetes Molekulargewicht70 kDa
GenBank-ZugangsnummerNM_005618
Gene symbol DLL1
Gene ID (NCBI) 28514
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Antigen-Affinitätsreinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

The Notch pathway functions during diverse developmental and physiological processes. Notch receptor and its ligands, Delta and Jagged, are transmembrane proteins with large extracellular domains that consist primarily of epidermal growth factor (EGF)-like repeats (PMID: 16921404). Delta-like protein 1 (DLL1, also named as Delta1) is a ligand of NOTCH1, NOTCH2 and NOTCH3 receptors that binds the extracellular domain of Notch receptor in a cis and trans fashion manner (PMID: 11006133). DLL1 play a role in development of the central nervous system, somites and lymphocytes (PMID: 31353024). It is overexpressed in various cancers and is involved in the regulation of cancer progression (PMID: 32440154). DLL1 undergoes proteolytic processing in its extracellular domain by ADAM proteases and gamma-secretase (PMID: 17107962; 12794186).