DR4 Rekombinanter Antikörper

DR4 Rekombinant Antikörper für FC

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

FC

Konjugation

Unkonjugiert

CloneNo.

250737E11

Kat-Nr. : 98511-1-PBS

Synonyme

APO2, CD261, Death receptor 4, TNF-related apoptosis-inducing ligand receptor 1, TNFRSF10A

---

• 

  FC experiment of HEL92.1.7 using 98511-1-RR (same clone as 98511-1-PBS)

  1x10^6 HEL92.1.7 (left) or 1x10^6 PBMC cells (right) were surface stained with 0.15 ug Anti-Human DR4 Rabbit RecAb (98511-1-RR, Clone: 250737E11) (red) or 0.15 ug Rabbit IgG Isotype Control RecAb (98136-1-RR, Clone: 240953C9) (blue), and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were not fixed. This data was developed using the same antibody clone with 98511-1-PBS in a different storage buffer formulation.

---

Geprüfte Anwendungen

Produktinformation

98511-1-PBS bindet in FC DR4 und zeigt Reaktivität mit human

• Getestete Reaktivität: human
• Wirt / Isotyp: Kaninchen / IgG
• Klonalität: Rekombinant
• Typ: Antikörper
• Immunogen: DR4 fusion protein Eg4600
• Vollständiger Name: tumor necrosis factor receptor superfamily, member 10a
• Berechnetes Molekulargewicht: 50 kDa
• GenBank-Zugangsnummer: BC012866
• Gene symbol: DR4
• Gene ID (NCBI): 8797
• Konjugation: Unkonjugiert
• Form: Liquid
• Reinigungsmethode: Protein-A-Reinigung
• Lagerungspuffer: PBS only
• Lagerungsbedingungen: Store at -80°C.

Hintergrundinformationen

Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) is a member of the TNF superfamily. TRAIL activates apoptosis through the death receptors DR4 (also known as TRAILR1 and TNFRSF10A) and DR5 (also known as TRAILR2, KILLER and TNFRSF10B). DR4 and DR5 are single-pass type I membrane proteins that contain intracellular death domains (DD) and upon activation mediate apoptotic signals (PMID: 11163110). Binding of TRAIL to DR4 or DR5 results in receptor oligomerization and recruitment of FAS-associated protein with death domain (FADD) and caspase 8 to form a functional death-inducing signalling complex (DISC). Upon DISC formation, caspase 8 is cleaved and activated, which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis (PMID: 18813321). DR4 or DR5 promotes the activation of NF-kappa-B and play an important role in inflammation (PMID: 9430227, 19434100).