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DR5-Specific Polyklonaler Antikörper

DR5-Specific Polyklonal Antikörper für WB, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

WB, Indirect ELISA

Konjugation

Unkonjugiert

Kat-Nr. : 15497-1-PBS

Synonyme

Filter:
  • Western Blot (WB) analysis of PC-3 cells using DR5-Specific Polyclonal antibody (15497-1-AP)

    WB analysis of PC-3 cells using 15497-1-AP (same clone as 15497-1-PBS)

    WB result of 15497-1-AP (TNFRSF10B, DR5 antibody) with PC-3 cell, untreated or treated with tunicamysin. This data was developed using the same antibody clone with 15497-1-PBS in a different storage buffer formulation.

  • Western Blot (WB) analysis of HL-60 cells using DR5-Specific Polyclonal antibody (15497-1-AP)

    WB analysis of HL-60 using 15497-1-AP (same clone as 15497-1-PBS)

    HL-60 cells were subjected to SDS PAGE followed by western blot with 15497-1-AP (TNFRSF10B-Specific antibody) at dilution of 1:200 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 15497-1-PBS in a different storage buffer formulation.

Geprüfte Anwendungen

Produktinformation

15497-1-PBS bindet in WB, Indirect ELISA DR5-Specific und zeigt Reaktivität mit human

Getestete Reaktivität human
Wirt / Isotyp Kaninchen / IgG
Klonalität Polyklonal
Typ Antikörper
Immunogen Peptid
Vollständiger Name tumor necrosis factor receptor superfamily, member 10b
Berechnetes Molekulargewicht 48 kDa
Beobachtetes Molekulargewicht 58-60 kDa, 45-50 kDa, 32 kDa
GenBank-ZugangsnummerNM_003842
Gene symbol DR5
Gene ID (NCBI) 8795
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Antigen-Affinitätsreinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

TNFRSF10B, also known as CD262, DR5, TRAILR2, TRICK2 and KILLER, is a widely expressed single-pass type I membrane protein belonging to the tumour necrosis factor receptor superfamily (TNFRSF). It is a receptor for TNF-related apoptosis-inducing ligand (TRAIL), which is a member of the tumor necrosis factor (TNF) family of cytokines and induces apoptosis in a wide variety of cells (PMID: 9311998). TNFRSF10B contains two extracellular cysteine-rich repeats, typical for TNF receptor (TNFR) family members, and a cytoplasmic death domain (DD), through which TNFRSF10B is capable to transmit the apoptotic signal (PMID: 9311998; 20531300). In PDAC cells, especially Panc89 cells, it expresses additionally to the approximately 48 and 40 kDa forms of DR5, a faster migrating variant of DR5 of about 32 kDa(PMID:20354842). The TRAIL receptor 2 (death receptor 5, or DR5) forms receptor dimers in a ligand-dependent manner, and these receptor dimers exist within high molecular weight networks(Dr. Jonathan N. Sachs,2012).