DRAM Polyklonaler Antikörper

DRAM Polyklonal Antikörper für WB, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

WB, Indirect ELISA

Konjugation

Unkonjugiert

Kat-Nr. : 31777-1-PBS

Synonyme

DRAM1, DNA damage-regulated autophagy modulator protein 1, Damage-regulated autophagy modulator

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  WB analysis using 31777-1-AP (same clone as 31777-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 31777-1-AP (DRAM antibody) at dilution of 1:1500 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 31777-1-PBS in a different storage buffer formulation.

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Geprüfte Anwendungen

Produktinformation

31777-1-PBS bindet in WB, Indirect ELISA DRAM und zeigt Reaktivität mit human

• Getestete Reaktivität: human
• Wirt / Isotyp: Kaninchen / IgG
• Klonalität: Polyklonal
• Typ: Antikörper
• Immunogen: DRAM fusion protein Ag33711
• Vollständiger Name: damage-regulated autophagy modulator
• Berechnetes Molekulargewicht: 26 kDa
• Beobachtetes Molekulargewicht: 33 kDa
• GenBank-Zugangsnummer: BC018435
• Gene symbol: DRAM
• Gene ID (NCBI): 55332
• Konjugation: Unkonjugiert
• Form: Liquid
• Reinigungsmethode: Antigen-Affinitätsreinigung
• Lagerungspuffer: PBS only
• Lagerungsbedingungen: Store at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

Damage-regulated autophagy modulator (DRAM) is a lysosomal membrane protein of autophagy that enriches in lung tissue and plays a central role in p53/TP53-mediated apoptosis (PMID: 16839881), which increased autophagy flux by promoting lysosomal acidification and protease activation (PMID: 23696801). It has 238 amino acids and six hydrophobic transmembrane regions. Reports show DRAM to be downregulated in squamous cancers, indicating a selective pressure to lose DRAM during tumor development (PMID: 17102582). Overexpression of DRAM1 can promote mitophagy and enhance mitochondrial function (PMID: 31204316).