Desmocollin 2 Monoklonaler Antikörper

Desmocollin 2 Monoklonal Antikörper für WB, IF-P, ELISA

Wirt / Isotyp

Maus / IgG2a

Getestete Reaktivität

human, Maus, Ratte

Anwendung

WB, IF-P, ELISA

Konjugation

Unkonjugiert

Publikationen(6)

CloneNo.

1H8G1

Kat-Nr. : 60239-1-Ig

Synonyme

DSC2, 1H8G1, ARVD11, Cadherin family member 2, CDHF2



Geprüfte Anwendungen

Erfolgreiche Detektion in WBHEK-293-Zellen, Raji-Zellen
Erfolgreiche Detektion in IF-PMausherzgewebe, Rattenherzgewebe

Empfohlene Verdünnung

AnwendungVerdünnung
Western Blot (WB)WB : 1:1000-1:4000
Immunfluoreszenz (IF)-PIF-P : 1:200-1:800
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, check data in validation data gallery

Veröffentlichte Anwendungen

WBSee 4 publications below
IFSee 1 publications below

Produktinformation

60239-1-Ig bindet in WB, IF-P, ELISA Desmocollin 2 und zeigt Reaktivität mit human, Maus, Ratten

Getestete Reaktivität human, Maus, Ratte
In Publikationen genannte Reaktivitäthuman
Wirt / Isotyp Maus / IgG2a
Klonalität Monoklonal
Typ Antikörper
Immunogen Desmocollin 2 fusion protein Ag5450
Vollständiger Name desmocollin 2
Berechnetes Molekulargewicht 100 kDa
Beobachtetes Molekulargewicht 110 kDa
GenBank-ZugangsnummerBC063291
Gene symbol Desmocollin 2
Gene ID (NCBI) 1824
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Protein-A-Reinigung
Lagerungspuffer PBS with 0.02% sodium azide and 50% glycerol
LagerungsbedingungenBei -20°C lagern. Nach dem Versand ein Jahr lang stabil Aliquotieren ist bei -20oC Lagerung nicht notwendig. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

Desmocollin 2 (DSC2) is a member of the desmocollin subfamily of the cadherin superfamily. The desmocollins (DSC1-3), along with the desmogleins (DSG1-4), are found primarily in epithelia and cardiac muscle where they constitute the adhesive proteins of the intercellular desmosome junctions and are required for cell adhesion and desmosome formation. Mutations in DSC2 gene are associated with arrhythmogenic right ventricular dysplasia-11.

Protokolle

PRODUKTSPEZIFISCHE PROTOKOLLE
WB protocol for Desmocollin 2 antibody 60239-1-IgProtokoll herunterladen
IF protocol for Desmocollin 2 antibody 60239-1-IgProtokoll herunterladen
STANDARD-PROTOKOLLE
Klicken Sie hier, um unsere Standardprotokolle anzuzeigen

Publikationen

SpeciesApplicationTitle
humanWB

J Cell Biol

DPM1 modulates desmosomal adhesion and epidermal differentiation through SERPINB5

Authors - Maitreyi Rathod
humanWB

Acta Physiol (Oxf)

Clustering of desmosomal cadherins by desmoplakin is essential for cell-cell adhesion.

Authors - Marie-Therès Wanuske
humanWB

PLoS Pathog

Porphyromonas gingivalis induces penetration of lipopolysaccharide and peptidoglycan through the gingival epithelium via degradation of junctional adhesion molecule 1.

Authors - Hiroki Takeuchi
humanIF

Stem Cell Res Ther

Both Wnt signaling and epidermal stem cell-derived extracellular vesicles are involved in epidermal cell growth.

Authors - Ling Leng
humanWB

Mol Ther Oncolytics

Exosomal miR-205-5p enhances angiogenesis and nasopharyngeal carcinoma metastasis by targeting desmocollin-2.

Authors - Wenjuan Yang
Human

Heliyon

The role of FERMT2 in the tumor microenvironment and immunotherapy in pan-cancer using comprehensive single-cell and bulk sequencing

Authors - Guang-Hao Wu

Rezensionen

The reviews below have been submitted by verified Proteintech customers who received an incentive for providing their feedback.


FH

Jane (Verified Customer) (02-03-2022)

A very weak and smear band found around the right molecular weight. However, the quality is not good enough to do any analysis or generate results.

  • Applications: Western Blot
  • Primary Antibody Dilution: 1:200
  • Cell Tissue Type: Cardiomyoyctes
FH

Jing (Verified Customer) (02-04-2020)

Tested in hiPSC-derived cardiomyocytes, it showed band around 130Kd.

  • Applications: Western Blot,
  • Primary Antibody Dilution: 1:1000
  • Cell Tissue Type: hiPSC-derived cardiomyocytes