DUSP10 Polyklonaler Antikörper

DUSP10 Polyklonal Antikörper für WB, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human, Maus, Ratte

Anwendung

WB, Indirect ELISA

Konjugation

Unkonjugiert

Kat-Nr. : 30493-1-PBS

Synonyme

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  WB analysis using 30493-1-AP (same clone as 30493-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 30493-1-AP (DUSP10 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 30493-1-PBS in a different storage buffer formulation.

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Geprüfte Anwendungen

Produktinformation

30493-1-PBS bindet in WB, Indirect ELISA DUSP10 und zeigt Reaktivität mit human, Maus, Ratten

• Getestete Reaktivität: human, Maus, Ratte
• Wirt / Isotyp: Kaninchen / IgG
• Klonalität: Polyklonal
• Typ: Antikörper
• Immunogen: DUSP10 fusion protein Ag32718
• Vollständiger Name: dual specificity phosphatase 10
• Beobachtetes Molekulargewicht: 53 kDa
• GenBank-Zugangsnummer: BC031405
• Gene symbol: DUSP10
• Gene ID (NCBI): 11221
• Konjugation: Unkonjugiert
• Form: Liquid
• Reinigungsmethode: Antigen-Affinitätsreinigung
• Lagerungspuffer: PBS only
• Lagerungsbedingungen: Store at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

DUSP10, also known as MKP5, is a member of the MKPs subfamily involved in cell proliferation, differentiation, and migration. DUSP10 is a dual specificity phosphatase capable of dephosphorylating both pTyr and pThr residues of activated MAPKs with different affinities. It has been shown that isoforms of the p38 and JNK subfamilies are selectively and more effectively dephosphorylated than ERK subfamily members. DUSP10 has been proposed as a target for therapeutic treatment of atherosclerosis, since DUSP10 inhibition reduces NF-κB-induced TNF-α expression and increases TGF-β1 levels in this disease (PMID: 30939861).