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DYRK2 Polyklonaler Antikörper

DYRK2 Polyklonal Antikörper für WB, IF/ICC, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human, Maus, Ratte

Anwendung

WB, IF/ICC, Indirect ELISA

Konjugation

Unkonjugiert

Kat-Nr. : 21979-1-PBS

Synonyme

Dual specificity tyrosine-phosphorylation-regulated kinase 2, DYRK 2, EC:2.7.12.1

Filter:
  • Western Blot (WB) analysis of various lysates using DYRK2 Polyclonal antibody (21979-1-AP)

    WB analysis using 21979-1-AP (same clone as 21979-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 21979-1-AP (DYRK2 antibody) at dilution of 1:1500 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 21979-1-PBS in a different storage buffer formulation.

  • Immunofluorescence (IF) / fluorescent staining of K-562 cells using DYRK2 Polyclonal antibody (21979-1-AP)

    IF Staining of K-562 using 21979-1-AP (same clone as 21979-1-PBS)

    Immunofluorescent analysis of (4% PFA) fixed K-562 cells using DYRK2 antibody (21979-1-AP) at dilution of 1:200 and CoraLite®488-Conjugated Goat Anti-Rabbit IgG(H+L) (SA00013-2). This data was developed using the same antibody clone with 21979-1-PBS in a different storage buffer formulation.

Geprüfte Anwendungen

Produktinformation

21979-1-PBS bindet in WB, IF/ICC, Indirect ELISA DYRK2 und zeigt Reaktivität mit human, Maus, Ratten

Getestete Reaktivität human, Maus, Ratte
Wirt / Isotyp Kaninchen / IgG
Klonalität Polyklonal
Typ Antikörper
Immunogen DYRK2 fusion protein Ag13480
Vollständiger Name dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2
Berechnetes Molekulargewicht 67 kDa
Beobachtetes Molekulargewicht67~70 kDa
GenBank-ZugangsnummerBC006375
Gene symbol DYRK2
Gene ID (NCBI) 8445
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Antigen-Affinitätsreinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

DYRK (Dual-specificity tyrosine phosphorylation-regulated kinase 2) is the only member of the Dual-specificity tYrosine phosphorylation-Regulated Kinase (DYRK) family that functions as a kinase activity-independent scaffold for an E3 ubiquitin ligase complex (PMID: 33376136). DYRK2 is involved in cell survival, development, differentiation, gene transcription, proteasomal regulation, and microtubule formation. DYRK2 is a key regulator of cell cycle and apoptosis in response to DNA damage via phosphorylation of p53. DYRK2 has two isoforms and is mostly localized in the cytoplasm; however, it accumulates in the nucleus under genotoxic stress conditions (PMID: 31505048, 37886981).