DcR2 Polyklonaler Antikörper

DcR2 Polyklonal Antikörper für WB, IHC, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

WB, IHC, Indirect ELISA

Konjugation

Unkonjugiert

Kat-Nr. : 16781-1-PBS

Synonyme

CD264, Decoy receptor 2, TNF-related apoptosis-inducing ligand receptor 4, TNFRSF10D, TRAIL R4

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  WB analysis using 16781-1-AP (same clone as 16781-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 16781-1-AP (DcR2 antibody) at dilution of 1:2000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 16781-1-PBS in a different storage buffer formulation.

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  IHC staining of human kidney using 16781-1-AP (same clone as 16781-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human kidney using 16781-1-AP (DcR2 antibody) at dilution of 1:50 (under 10x lens). This data was developed using the same antibody clone with 16781-1-PBS in a different storage buffer formulation.

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  IHC staining of human kidney using 16781-1-AP (same clone as 16781-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human kidney using 16781-1-AP (DcR2 antibody) at dilution of 1:50 (under 40x lens). This data was developed using the same antibody clone with 16781-1-PBS in a different storage buffer formulation.

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Geprüfte Anwendungen

Produktinformation

16781-1-PBS bindet in WB, IHC, Indirect ELISA DcR2 und zeigt Reaktivität mit human

• Getestete Reaktivität: human
• Wirt / Isotyp: Kaninchen / IgG
• Klonalität: Polyklonal
• Typ: Antikörper
• Immunogen: DcR2 fusion protein Ag10208
• Vollständiger Name: tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain
• Berechnetes Molekulargewicht: 386 aa, 42 kDa
• Beobachtetes Molekulargewicht: 50-55 kDa
• GenBank-Zugangsnummer: BC052270
• Gene symbol: DcR2
• Gene ID (NCBI): 8793
• Konjugation: Unkonjugiert
• Form: Liquid
• Reinigungsmethode: Antigen-Affinitätsreinigung
• Lagerungspuffer: PBS only
• Lagerungsbedingungen: Store at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

Decoy receptor 2 (DcR2) is a member of the tumor necrosis factor receptor (TNFR) superfamily. It functions as a decoy receptor for TNF-related apoptosis-inducing ligand (TRAIL), thereby inhibiting TRAIL-mediated apoptosis (PMID: 15538968; 9537512). It has been considered a tentative marker of cellular senescence (PMID: 16079833; 22751116). Additionally, DCR2 has been implicated in the regulation of renal fibrosis and cell senescence, contributing to the pathogenesis of diabetic nephropathy (PMID: 35661704).