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Dectin-1 Polyklonaler Antikörper

Dectin-1 Polyklonal Antikörper für WB, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

WB, Indirect ELISA

Konjugation

Unkonjugiert

Kat-Nr. : 22809-1-PBS

Synonyme

Filter:
  • Western Blot (WB) analysis of various lysates using Dectin-1 Polyclonal antibody (22809-1-AP)

    WB analysis using 22809-1-AP (same clone as 22809-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 22809-1-AP (Dectin-1 antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 22809-1-PBS in a different storage buffer formulation.

Geprüfte Anwendungen

Produktinformation

22809-1-PBS bindet in WB, Indirect ELISA Dectin-1 und zeigt Reaktivität mit human

Getestete Reaktivität human
Wirt / Isotyp Kaninchen / IgG
Klonalität Polyklonal
Typ Antikörper
Immunogen Dectin-1 fusion protein Ag18924
Vollständiger Name C-type lectin domain family 7, member A
Berechnetes Molekulargewicht 247 aa, 28 kDa
Beobachtetes Molekulargewicht45 kDa
GenBank-ZugangsnummerBC013385
Gene symbol Dectin-1
Gene ID (NCBI) 64581
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Antigen-Affinitätsreinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

Dectin-1, also known as CLEC7A or CD369, is a type II membrane receptor consisting of an extracellular C-terminal C-type lectin domain, a short stalk region, a single transmembrane domain and a short N-terminal cytoplasmic tail, which contains an immunoreceptor tyrosine-based activation motif (PMID: 10779524; 21612412). Dectin-1 is expressed on monocytes, macrophages, neutrophils, dendritic cells and a subpopulation of T cells (PMID: 12244185). Dectin-1 plays a role in the innate immune response. It functions as a pattern-recognition receptor and recognizes a variety of β-glucans from fungi, plants and bacteria. Dectin-1 may also participate in orchestrating the adaptive immune response (PMID: 21612412). The apparent molecular weight is larger than the calculated molecular weight due to glycosylation (PMID: 10779524).