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DjC8 Polyklonaler Antikörper

DjC8 Polyklonal Antikörper für WB, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

WB, Indirect ELISA

Konjugation

Unkonjugiert

Kat-Nr. : 32709-1-PBS

Synonyme

DnaJ homolog subfamily C member 8, DNAJC8, HSPC315, HSPC331, SPF31

Filter:
  • Western Blot (WB) analysis of various lysates using DjC8 Polyclonal antibody (32709-1-AP)

    WB analysis using 32709-1-AP (same clone as 32709-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 32709-1-AP (DNAJC8 antibody) at dilution of 1:2000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 32709-1-PBS in a different storage buffer formulation.

Geprüfte Anwendungen

Produktinformation

32709-1-PBS bindet in WB, Indirect ELISA DjC8 und zeigt Reaktivität mit human

Getestete Reaktivität human
Wirt / Isotyp Kaninchen / IgG
Klonalität Polyklonal
Typ Antikörper
Immunogen DjC8 fusion protein Ag38520
Vollständiger Name DnaJ (Hsp40) homolog, subfamily C, member 8
Berechnetes Molekulargewicht30kDa，253aa
Beobachtetes Molekulargewicht30 kDa
GenBank-ZugangsnummerNM_014280.2
Gene symbol DNAJC8
Gene ID (NCBI) 22826
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Antigen-Affinitätsreinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

DjC8 (C8, a member of DNAJ heat shock protein family), also known as DNAJC8, which is a highly conserved protein, belonging to heat shock protein 40(HSP40) family. The protein is expressed in many cell types, including central nervous system macrophages, cerebellar inhibitory neurons, choroid plexus epithelial cells of ventricles, oligodendrocyte precursor cells and so on. In normal tissues, the expression level of DjC8 is relatively low, but it is high in some tissues such as testis, skeletal muscle and spleen. In hepatocellular carcinoma, the high expression of DjC8 is related to poor prognosis. Knocking down DjC8 can inhibit the proliferation, migration and invasion of hepatocellular carcinoma cells, and reduce the IC50 value of sorafenib, indicating that it may be a potential therapeutic target and prognostic marker for hepatocellular carcinoma. In addition, DjC8 is regulated by TIG1 in cervical cancer and participates in glycolysis. DjC8 contains a conserved J domain, which can interact with HSP70 and activate its ATPase activity, thus participating in the folding, unfolding, transport and degradation of protein. The molecular weight of DjC8 is 30 kDa.