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E-cadherin Monoklonaler Antikörper
E-cadherin Monoklonal Antikörper für WB, IHC, IF/ICC, IF-P, IF-Fro, Indirect ELISA
Wirt / Isotyp
Maus / IgG2b
Getestete Reaktivität
Hausschwein, human, Maus, Ratte
Anwendung
WB, IHC, IF/ICC, IF-P, IF-Fro, Indirect ELISA
Konjugation
Unkonjugiert
CloneNo.
6B11F11
Kat-Nr. : 60335-1-PBS
Synonyme
Geprüfte Anwendungen
Produktinformation
60335-1-PBS bindet in WB, IHC, IF/ICC, IF-P, IF-Fro, Indirect ELISA E-cadherin und zeigt Reaktivität mit Hausschwein, human, Maus, Ratten
Getestete Reaktivität | Hausschwein, human, Maus, Ratte |
Wirt / Isotyp | Maus / IgG2b |
Klonalität | Monoklonal |
Typ | Antikörper |
Immunogen | E-cadherin fusion protein Ag15085 |
Vollständiger Name | cadherin 1, type 1, E-cadherin (epithelial) |
Berechnetes Molekulargewicht | 882 aa, 97 kDa |
Beobachtetes Molekulargewicht | 120 kDa |
GenBank-Zugangsnummer | BC141838 |
Gene symbol | E-cadherin |
Gene ID (NCBI) | 999 |
Konjugation | Unkonjugiert |
Form | Liquid |
Reinigungsmethode | Protein-A-Reinigung |
Lagerungspuffer | PBS only |
Lagerungsbedingungen | Store at -80°C. 20ul Größen enthalten 0,1% BSA. |
Hintergrundinformationen
Cadherins are a family of transmembrane glycoproteins that mediate calcium-dependent cell-cell adhesion and play an important role in the maintenance of normal tissue architecture. E-cadherin (epithelial cadherin), also known as CDH1 (cadherin 1) or CAM 120/80, is a classical member of the cadherin superfamily which also include N-, P-, R-, and B-cadherins. E-cadherin is expressed on the cell surface in most epithelial tissues. The extracellular region of E-cadherin establishes calcium-dependent homophilic trans binding, providing specific interaction with adjacent cells, while the cytoplasmic domain is connected to the actin cytoskeleton through the interaction with p120-, α-, β-, and γ-catenin (plakoglobin). E-cadherin is important in the maintenance of the epithelial integrity, and is involved in mechanisms regulating proliferation, differentiation, and survival of epithelial cell. E-cadherin may also play a role in tumorigenesis. It is considered to be an invasion suppressor protein and its loss is an indicator of high tumor aggressiveness.