E-cadherin Rekombinanter Antikörper
E-cadherin Rekombinant Antikörper für WB, IHC, IF/ICC, ELISA
Wirt / Isotyp
Kaninchen / IgG
Getestete Reaktivität
human
Anwendung
WB, IHC, IF/ICC, ELISA
Konjugation
Unkonjugiert
CloneNo.
240159A1
Kat-Nr. : 80541-7-PBS
Synonyme
Geprüfte Anwendungen
Produktinformation
80541-7-PBS bindet in WB, IHC, IF/ICC, ELISA E-cadherin und zeigt Reaktivität mit human
Getestete Reaktivität | human |
Wirt / Isotyp | Kaninchen / IgG |
Klonalität | Rekombinant |
Typ | Antikörper |
Immunogen | E-cadherin fusion protein Ag14973 |
Vollständiger Name | cadherin 1, type 1, E-cadherin (epithelial) |
Berechnetes Molekulargewicht | 882 aa, 97 kDa |
Beobachtetes Molekulargewicht | 135 kDa |
GenBank-Zugangsnummer | BC141838 |
Gene symbol | E-cadherin |
Gene ID (NCBI) | 999 |
Konjugation | Unkonjugiert |
Form | Liquid |
Reinigungsmethode | Protein A purfication |
Lagerungspuffer | PBS only |
Lagerungsbedingungen | Store at -80°C. 20ul Größen enthalten 0,1% BSA. |
Hintergrundinformationen
Cadherins are a family of transmembrane glycoproteins that mediate calcium-dependent cell-cell adhesion and play an important role in the maintenance of normal tissue architecture. E-cadherin (epithelial cadherin), also known as CDH1 (cadherin 1) or CAM 120/80, is a classical member of the cadherin superfamily which also include N-, P-, R-, and B-cadherins. E-cadherin is expressed on the cell surface in most epithelial tissues. The extracellular region of E-cadherin establishes calcium-dependent homophilic trans binding, providing specific interaction with adjacent cells, while the cytoplasmic domain is connected to the actin cytoskeleton through the interaction with p120-, α-, β-, and γ-catenin (plakoglobin). E-cadherin is important in the maintenance of the epithelial integrity, and is involved in mechanisms regulating proliferation, differentiation, and survival of epithelial cell. E-cadherin may also play a role in tumorigenesis. It is considered to be an invasion suppressor protein and its loss is an indicator of high tumor aggressiveness.