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ECE1 Polyklonaler Antikörper

ECE1 Polyklonal Antikörper für WB, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

WB, Indirect ELISA

Konjugation

Unkonjugiert

Kat-Nr. : 27245-1-PBS

Synonyme

Filter:
  • Western Blot (WB) analysis of various lysates using ECE1 Polyclonal antibody (27245-1-AP)

    WB analysis using 27245-1-AP (same clone as 27245-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 27245-1-AP (ECE1 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 27245-1-PBS in a different storage buffer formulation.

Geprüfte Anwendungen

Produktinformation

27245-1-PBS bindet in WB, Indirect ELISA ECE1 und zeigt Reaktivität mit human

Getestete Reaktivität human
Wirt / Isotyp Kaninchen / IgG
Klonalität Polyklonal
Typ Antikörper
Immunogen ECE1 fusion protein Ag26124
Vollständiger Name endothelin converting enzyme 1
Beobachtetes Molekulargewicht87-110 kDa
GenBank-ZugangsnummerBC126257
Gene symbol ECE1
Gene ID (NCBI) 1889
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Antigen-Affinitätsreinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

ECE1, Endothelin-converting enzyme 1, also known as ECE. It is located in cell membrane, and it has 4 isoforms. All isoforms are expressed in umbilical vein endothelial cells, polynuclear neutrophils, fibroblasts, atrium cardiomyocytes and ventricles. Isoforms A, B and C are also expressed in placenta, lung, heart, adrenal gland and phaeochromocytoma; isoforms A and C in liver, testis and small intestine; isoform B, C and D in endothelial cells and umbilical vein smooth muscle cells; isoforms C and D in saphenous vein cells, and isoform C in kidney (PMID: 9396733). The protein encoded by this gene is involved in proteolytic processing of endothelin precursors to biologically active peptides. Mutations in this gene are associated with Hirschsprung disease, cardiac defects and autonomic dysfunction. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. The calculated molecular weight of ECE1 is 87 kDa, as a result of glycosylation, the apparent molecular mass of ECE1 is approximately 87-110 kDa.