EDNRB Polyklonaler Antikörper

EDNRB Polyklonal Antikörper für WB, IHC, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human, Maus

Anwendung

WB, IHC, Indirect ELISA

Konjugation

Unkonjugiert

Kat-Nr. : 20964-1-PBS

Synonyme

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  WB analysis of HEK-293 using 20964-1-AP (same clone as 20964-1-PBS)

  HEK-293 cells were subjected to SDS PAGE followed by western blot with 20964-1-AP (EDNRB antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 20964-1-PBS in a different storage buffer formulation.

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  WB analysis of mouse placenta using 20964-1-AP (same clone as 20964-1-PBS)

  mouse placenta tissue were subjected to SDS PAGE followed by western blot with 20964-1-AP (EDNRB antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 20964-1-PBS in a different storage buffer formulation.

• 

  WB analysis of human placenta using 20964-1-AP (same clone as 20964-1-PBS)

  human placenta tissue were subjected to SDS PAGE followed by western blot with 20964-1-AP (EDNRB antibody) at dilution of 1:600 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 20964-1-PBS in a different storage buffer formulation.

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  IHC staining of human placenta using 20964-1-AP (same clone as 20964-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human placenta tissue slide using 20964-1-AP (EDNRB Antibody) at dilution of 1:50 (under 10x lens). This data was developed using the same antibody clone with 20964-1-PBS in a different storage buffer formulation.

• 

  IHC staining of human placenta using 20964-1-AP (same clone as 20964-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human placenta tissue slide using 20964-1-AP (EDNRB Antibody) at dilution of 1:50 (under 40x lens). This data was developed using the same antibody clone with 20964-1-PBS in a different storage buffer formulation.

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Geprüfte Anwendungen

Produktinformation

20964-1-PBS bindet in WB, IHC, Indirect ELISA EDNRB und zeigt Reaktivität mit human, Maus

• Getestete Reaktivität: human, Maus
• Wirt / Isotyp: Kaninchen / IgG
• Klonalität: Polyklonal
• Typ: Antikörper
• Immunogen: Peptid
• Vollständiger Name: endothelin receptor type B
• Berechnetes Molekulargewicht: 50 kDa
• Beobachtetes Molekulargewicht: 53-60 kDa
• GenBank-Zugangsnummer: NM_000115
• Gene symbol: EDNRB
• Gene ID (NCBI): 1910
• Konjugation: Unkonjugiert
• Form: Liquid
• Reinigungsmethode: Antigen-Affinitätsreinigung
• Lagerungspuffer: PBS only
• Lagerungsbedingungen: Store at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

EDNRB (endothelin receptor type B) is a G-protein coupled heptahelical endothelin-1 (EDN1) receptor. EDN1, a known mediator of human myometrial contraction in vitro, belongs to a family of three 21-amino acid isopeptides (PMID:18497345). EDNRB is a 442-residue protein expressed post-natally in many tissues, particularly in the myenteric plexus, mucosal layer, ganglia, and blood vessels of the submucosa of the colon (PMID:11434563). Moreover, Both the EDNRA and EDNRB are expressed in ships and can be bound by EDN1. Still, while EDNRA mediates a constrictive effect, EDNRB is involved in vasorelaxation and functions as a clearance receptor that scavenges circulating EDN1 (PMID:30171849).