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EGFR Rekombinanter Antikörper

EGFR Rekombinant Antikörper für FC

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

FC

Konjugation

Unkonjugiert

CloneNo.

242684A1

Kat-Nr. : 98344-1-PBS

Synonyme

242684A1, EGF R, EGF Receptor , Epidermal growth factor receptor, Proto-oncogene c-ErbB-1

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  • Flow cytometry (FC) experiment of A431 cells using Anti-Human EGFR Rabbit Recombinant Antibody (98344-1-RR)

    FC experiment of A431 using 98344-1-RR (same clone as 98344-1-PBS)

    1x10^6 A431 cells were surface stained with 0.25 ug Anti-Human EGFR Rabbit RecAb (98344-1-RR, Clone: 242684A1) (red) or 0.25 ug Rabbit IgG Isotype Control RecAb (98136-1-RR, Clone: 240953C9) (blue), and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were not fixed. This data was developed using the same antibody clone with 98344-1-PBS in a different storage buffer formulation.

  • Affinity and Kinetic Characterization of 98344-1-RR

    Affinity and Kinetic Characterization of 98344-1-RR

    Biolayer interferometry (BLl) kinetic assays of 98344-1-RR against Human EGFR were performed. The affinity constant is 8.55 nM.

Geprüfte Anwendungen

Produktinformation

98344-1-PBS bindet in FC EGFR und zeigt Reaktivität mit human

Getestete Reaktivität human
Wirt / Isotyp Kaninchen / IgG
Klonalität Rekombinant
Typ Antikörper
Immunogen Rekombinantes Protein
Vollständiger Name epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)
Berechnetes Molekulargewicht134kd
GenBank-ZugangsnummerNM_005228.5
Gene symbol EGFR
Gene ID (NCBI) 1956
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Protein-A-Reinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C.

Hintergrundinformationen

EGFR, also named as ERBB1, is a cell-surface receptor for members of the epidermal growth factor family (EGF-family) of extracellular protein ligands. Binding of the protein to a ligand induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation. The gene resides on chromosome 7p12, encoding a 170 kDa membrane-associated glycoprotein. Recent studies have shown EGFR plays a critical role in cancer development and progression, including cell proliferation, apoptosis, angiogenesis, and metastatic spread. Mutations in this gene are associated with lung cancer.