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EMR2 Rekombinanter Antikörper

EMR2 Rekombinant Antikörper für WB, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

WB, Indirect ELISA

Konjugation

Unkonjugiert

CloneNo.

242042E3

Kat-Nr. : 84608-5-PBS

Synonyme

EGF-like module receptor 2, EGF like module receptor 2, CD312, Adhesion G protein-coupled receptor E2, ADGRE2

Filter:
  • Western Blot (WB) analysis of various lysates using EMR2 Recombinant antibody (84608-5-RR)

    WB analysis using 84608-5-RR (same clone as 84608-5-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 84608-5-RR (EMR2 antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 84608-5-PBS in a different storage buffer formulation.

  • Affinity and Kinetic Characterization of 84608-5-RR

    Affinity and Kinetic Characterization of 84608-5-RR

    Biolayer interferometry (BLl) kinetic assays of 84608-5-RR against Human EMR2 were performed. The affinity constant is 1.45 nM.

Geprüfte Anwendungen

Produktinformation

84608-5-PBS bindet in WB, Indirect ELISA EMR2 und zeigt Reaktivität mit human

Getestete Reaktivität human
Wirt / Isotyp Kaninchen / IgG
Klonalität Rekombinant
Typ Antikörper
Immunogen Rekombinantes Protein
Vollständiger Name egf-like module containing, mucin-like, hormone receptor-like 2
Berechnetes Molekulargewicht90 kDa
Beobachtetes Molekulargewicht75~90 kDa
GenBank-ZugangsnummerNM_013447.3
Gene symbol EMR2
Gene ID (NCBI) 30817
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Protein A purfication
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

EMR2 (Epidermal Growth Factor-like module-containing Mucin-like Hormone Receptor 2), also known as ADGRE2, is a member of the adhesion-GPCR family that contains extracellular EGF-like domains. EMR2 contains a total of five tandem EGF-like domains and expresses similar protein isoforms consisting of various numbers of EGF-like domains as a result of alternative RNA splicing (PMID: 10903844). EMR2 is restricted to myeloid cells including monocytes, macrophages, dendritic cells and granulocytes28 and its expression is highly regulated during monocyte/macrophage differentiation (PMID: 31969668).The ligation of EMR2 could increase neutrophil adhesion, migration and anti-microbial mediator production and could enhance the systemic inflammation (PMID: 27905560).