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EPOR Polyklonaler Antikörper

EPOR Polyklonal Antikörper für WB, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human, Maus, Ratte

Anwendung

WB, Indirect ELISA

Konjugation

Unkonjugiert

Kat-Nr. : 30766-1-PBS

Synonyme

EPO R, EPO-R, erythropoietin receptor

Filter:
  • Western Blot (WB) analysis of various lysates using EPOR Polyclonal antibody (30766-1-AP)

    WB analysis using 30766-1-AP (same clone as 30766-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 30766-1-AP (EPOR antibody) at dilution of 1:3000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 30766-1-PBS in a different storage buffer formulation.

Geprüfte Anwendungen

Produktinformation

30766-1-PBS bindet in WB, Indirect ELISA EPOR und zeigt Reaktivität mit human, Maus, Ratten

Getestete Reaktivität human, Maus, Ratte
Wirt / Isotyp Kaninchen / IgG
Klonalität Polyklonal
Typ Antikörper
Immunogen EPOR fusion protein Ag33956
Vollständiger Name erythropoietin receptor
Berechnetes Molekulargewicht55 kDa
Beobachtetes Molekulargewicht70 kDa
GenBank-ZugangsnummerNM_000121.4
Gene symbol EPOR
Gene ID (NCBI) 2057
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Antigen-Affinitätsreinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

Erythropoietin (EPO) receptor (EPOR) is a glycoprotein that belongs to the type I superfamily of single-transmembrane cytokine receptors. It consists of an extracellular domain that binds to the EPO ligand, a transmembrane domain and an intracellular domain. The interaction of EPO and EPOR triggers the activation of several signaling pathways that induce erythropoiesis, including JAK2/STAT5, PI3K/AKT, and MAPK (PMID: 34281163). EPOR is present on erythroid progenitor cells and has also been detected on a wide variety of non-hematopoietic cells (PMID: 36233351). The calculated molecular weight of EPOR is 55 kDa. EPOR undergoes posttranslational modification and the apparent molecular weight of 66-78 kDa has been reported (PMID: 8943308; 12088257).