EPS8L3 Polyklonaler Antikörper

EPS8L3 Polyklonal Antikörper für WB, ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

WB, ELISA

Konjugation

Unkonjugiert

Kat-Nr. : 32571-1-AP

Synonyme

Epidermal growth factor receptor kinase substrate 8-like protein 3, Epidermal growth factor receptor pathway substrate 8-related protein 3, EPS8 Signaling Adaptor L3, EPS8-like protein 3, EPS8R3

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  WB analysis using 32571-1-AP

  Various lysates were subjected to SDS PAGE followed by western blot with 32571-1-AP (EPS8L3 antibody) at dilution of 1:40000 incubated at room temperature for 1.5 hours.

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Geprüfte Anwendungen

• Erfolgreiche Detektion in WB: HepG2-Zellen

Empfohlene Verdünnung

• Western Blot (WB): WB : 1:5000-1:50000

It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Sample-dependent, check data in validation data gallery

Produktinformation

32571-1-AP bindet in WB, ELISA EPS8L3 und zeigt Reaktivität mit human

• Getestete Reaktivität: human
• Wirt / Isotyp: Kaninchen / IgG
• Klonalität: Polyklonal
• Typ: Antikörper
• Immunogen: EPS8L3 fusion protein Ag38525
• Vollständiger Name: EPS8-like 3
• Berechnetes Molekulargewicht: 67kDa，593aa
• Beobachtetes Molekulargewicht: 65 kDa
• GenBank-Zugangsnummer: NM_001319952.1
• Gene symbol: EPS8L3
• Gene ID (NCBI): 79574
• Konjugation: Unkonjugiert
• Form: Liquid
• Reinigungsmethode: Antigen-Affinitätsreinigung
• Lagerungspuffer: PBS with 0.02% sodium azide and 50% glycerol
• Lagerungsbedingungen: Bei -20°C lagern. Nach dem Versand ein Jahr lang stabil Aliquotieren ist bei -20^oC Lagerung nicht notwendig. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

EPS8L3 (epidermal growth factor receptor kinase substrate 8-like protein 3) is a member of the EPS8 family, encoding a protein associated with the epidermal growth factor receptor (EGFR) signaling pathway. Studies have shown that EPS8L3 is highly expressed in a variety of tumors, such as hepatocellular carcinoma (HCC), pancreatic cancer, and gastric cancer, and is closely associated with tumor proliferation, migration, and invasive ability. It promotes tumor cell proliferation and inhibits apoptosis by activating GSK3β and PI3K/AKT/mTOR signaling pathways. In addition, high expression of EPS8L3 is associated with poor prognosis in tumor patients and may serve as a biomarker for tumor diagnosis and prognostic assessment. Due to its important role in tumors, EPS8L3 is considered a potential therapeutic target, and its inhibition may enhance the efficacy of multi-target kinase inhibitors.