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ERCC8 Polyklonaler Antikörper

ERCC8 Polyklonal Antikörper für WB, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human, Maus

Anwendung

WB, Indirect ELISA

Konjugation

Unkonjugiert

Kat-Nr. : 15921-1-PBS

Synonyme

CKN1, CSA, DNA excision repair protein ERCC-8, ERCC Excision Repair 8, CSA Ubiquitin Ligase Complex Subunit

Filter:
  • Western Blot (WB) analysis of various lysates using ERCC8 Polyclonal antibody (15921-1-AP)

    WB analysis using 15921-1-AP (same clone as 15921-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 15921-1-AP (ERCC8 antibody) at dilution of 1:800 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 15921-1-PBS in a different storage buffer formulation.

Geprüfte Anwendungen

Produktinformation

15921-1-PBS bindet in WB, Indirect ELISA ERCC8 und zeigt Reaktivität mit human, Maus

Getestete Reaktivität human, Maus
Wirt / Isotyp Kaninchen / IgG
Klonalität Polyklonal
Typ Antikörper
Immunogen ERCC8 fusion protein Ag8734
Vollständiger Name excision repair cross-complementing rodent repair deficiency, complementation group 8
Berechnetes Molekulargewicht 396 aa, 44 kDa
Beobachtetes Molekulargewicht42 kDa
GenBank-ZugangsnummerBC009793
Gene symbol ERCC8
Gene ID (NCBI) 1161
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Antigen-Affinitätsreinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

ERCC8 (also known as Cockayne Syndrome A protein, CSA) is a critical nuclear protein that serves as a specific adapter component of the CRL4ᴱᴿᶜᶜ⁸ ubiquitin ligase complex. Its primary function is to play a central role in the transcription-coupled nucleotide excision repair pathway, specifically recognizing and repairing the template strands of actively transcribed genes damaged by factors such as ultraviolet radiation. Mutations in the ERCC8 gene cause Cockayne syndrome, an autosomal recessive disorder characterized by severe photosensitivity, premature aging, neurodevelopmental abnormalities, and sensorineural hearing loss. This demonstrates that ERCC8 is essential for maintaining transcriptional fidelity, neuronal survival, and combating oxidative stress. Therefore, ERCC8 is not only a key factor in DNA repair but also an important molecule for studying mechanisms of premature aging and neurobiology.